Gheorghiu L - Search Results

1

β-Endorphin mediates radiation therapy fatigue.

Hermann AL, Fell GL, Kemény LV, Fung CY, Held KD, Biggs PJ, Rivera PD, Bilbo SD, Igras V, Willers H, Kung J, Gheorghiu L, Hideghéty K, Mao J, Woolf CJ, Fisher DE. Hermann AL, et al. Among authors: gheorghiu l. Sci Adv. 2022 Dec 16;8(50):eabn6025. doi: 10.1126/sciadv.abn6025. Epub 2022 Dec 16. Sci Adv. 2022. PMID: 36525492 Free PMC article.

2

Lung cancer cell line screen links fanconi anemia/BRCA pathway defects to increased relative biological effectiveness of proton radiation.

Liu Q, Ghosh P, Magpayo N, Testa M, Tang S, Gheorghiu L, Biggs P, Paganetti H, Efstathiou JA, Lu HM, Held KD, Willers H. Liu Q, et al. Among authors: gheorghiu l. Int J Radiat Oncol Biol Phys. 2015 Apr 1;91(5):1081-9. doi: 10.1016/j.ijrobp.2014.12.046. Int J Radiat Oncol Biol Phys. 2015. PMID: 25832698

3

FANCD2-deficient human fibroblasts are hypersensitive to ionising radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions.

Kuhnert VM, Kachnic LA, Li L, Purschke M, Gheorghiu L, Lee R, Held KD, Willers H. Kuhnert VM, et al. Among authors: gheorghiu l. Int J Radiat Biol. 2009 Jun;85(6):523-31. doi: 10.1080/09553000902883810. Int J Radiat Biol. 2009. PMID: 19466639 Free PMC article.

4

PARP-1 inhibition with or without ionizing radiation confers reactive oxygen species-mediated cytotoxicity preferentially to cancer cells with mutant TP53.

Liu Q, Gheorghiu L, Drumm M, Clayman R, Eidelman A, Wszolek MF, Olumi A, Feldman A, Wang M, Marcar L, Citrin DE, Wu CL, Benes CH, Efstathiou JA, Willers H. Liu Q, et al. Among authors: gheorghiu l. Oncogene. 2018 May;37(21):2793-2805. doi: 10.1038/s41388-018-0130-6. Epub 2018 Mar 7. Oncogene. 2018. PMID: 29511347 Free PMC article.

5

DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity.

Willers H, Gheorghiu L, Liu Q, Efstathiou JA, Wirth LJ, Krause M, von Neubeck C. Willers H, et al. Among authors: gheorghiu l. Semin Radiat Oncol. 2015 Oct;25(4):237-50. doi: 10.1016/j.semradonc.2015.05.007. Epub 2015 May 14. Semin Radiat Oncol. 2015. PMID: 26384272 Free PMC article. Review.

6

EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks.

Wang M, Morsbach F, Sander D, Gheorghiu L, Nanda A, Benes C, Kriegs M, Krause M, Dikomey E, Baumann M, Dahm-Daphi J, Settleman J, Willers H. Wang M, et al. Among authors: gheorghiu l. Cancer Res. 2011 Oct 1;71(19):6261-9. doi: 10.1158/0008-5472.CAN-11-0213. Epub 2011 Aug 18. Cancer Res. 2011. PMID: 21852385 Free PMC article.

7

Detection of impaired homologous recombination repair in NSCLC cells and tissues.

Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle HN, Daly B, Ebright MI, Spencer C, O'Hara C, Whetstine JR, Benes CH, Sequist LV, Zou L, Dahm-Daphi J, Kachnic LA, Willers H. Birkelbach M, et al. Among authors: gheorghiu l. J Thorac Oncol. 2013 Mar;8(3):279-86. doi: 10.1097/JTO.0b013e31827ecf83. J Thorac Oncol. 2013. PMID: 23399959 Free PMC article.

8

A common Chk1-dependent phenotype of DNA double-strand break suppression in two distinct radioresistant cancer types.

Dinkelborg PH, Wang M, Gheorghiu L, Gurski JM, Hong TS, Benes CH, Juric D, Jimenez RB, Borgmann K, Willers H. Dinkelborg PH, et al. Among authors: gheorghiu l. Breast Cancer Res Treat. 2019 Apr;174(3):605-613. doi: 10.1007/s10549-018-05079-7. Epub 2019 Jan 3. Breast Cancer Res Treat. 2019. PMID: 30607635 Free PMC article.

9

Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity.

Marcar L, Bardhan K, Gheorghiu L, Dinkelborg P, Pfäffle H, Liu Q, Wang M, Piotrowska Z, Sequist LV, Borgmann K, Settleman JE, Engelman JA, Hata AN, Willers H. Marcar L, et al. Among authors: gheorghiu l. Cell Rep. 2019 Jun 18;27(12):3422-3432.e4. doi: 10.1016/j.celrep.2019.05.058. Cell Rep. 2019. PMID: 31216465 Free PMC article.

10

ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.

Sirbu BM, Lachmayer SJ, Wülfing V, Marten LM, Clarkson KE, Lee LW, Gheorghiu L, Zou L, Powell SN, Dahm-Daphi J, Willers H. Sirbu BM, et al. Among authors: gheorghiu l. PLoS One. 2011;6(8):e23053. doi: 10.1371/journal.pone.0023053. Epub 2011 Aug 12. PLoS One. 2011. PMID: 21857991 Free PMC article.

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