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Glutamate is an essential mediator in glutamine-amplified insulin secretion.
Han G, Takahashi H, Murao N, Gheni G, Yokoi N, Hamamoto Y, Asahara SI, Seino Y, Kido Y, Seino S. Han G, et al. Among authors: gheni g. J Diabetes Investig. 2021 Jun;12(6):920-930. doi: 10.1111/jdi.13497. Epub 2021 Feb 17. J Diabetes Investig. 2021. PMID: 33417747 Free PMC article.
Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion.
Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H, Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, Shibasaki T, Inagaki N, Bamba T, Mizoguchi A, Fukusaki E, Rorsman P, Seino S. Gheni G, et al. Cell Rep. 2014 Oct 23;9(2):661-73. doi: 10.1016/j.celrep.2014.09.030. Epub 2014 Oct 16. Cell Rep. 2014. PMID: 25373904 Free PMC article.
APOE genotypes modify the obesity paradox in dementia.
Shinohara M, Gheni G, Hitomi J, Bu G, Sato N. Shinohara M, et al. Among authors: gheni g. J Neurol Neurosurg Psychiatry. 2023 Sep;94(9):670-680. doi: 10.1136/jnnp-2022-331034. Epub 2023 Jul 6. J Neurol Neurosurg Psychiatry. 2023. PMID: 37414536 Free PMC article.