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5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation.
Scott SA, Dong WF, Ichinohasama R, Hirsch C, Sheridan D, Sanche SE, Geyer CR, Decoteau JF. Scott SA, et al. Among authors: geyer cr. Leuk Res. 2006 Jan;30(1):69-76. doi: 10.1016/j.leukres.2005.05.010. Epub 2005 Jul 25. Leuk Res. 2006. PMID: 16043219
Bcr-Abl induces autocrine IGF-1 signaling.
Lakshmikuttyamma A, Pastural E, Takahashi N, Sawada K, Sheridan DP, DeCoteau JF, Geyer CR. Lakshmikuttyamma A, et al. Among authors: geyer cr. Oncogene. 2008 Jun 19;27(27):3831-44. doi: 10.1038/onc.2008.8. Epub 2008 Feb 4. Oncogene. 2008. PMID: 18246120
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