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The Zinc-Binding Group Effect: Lessons from Non-Hydroxamic Acid Vorinostat Analogs.
J Med Chem. 2023 Jun 22;66(12):7698-7729. doi: 10.1021/acs.jmedchem.3c00226. Epub 2023 Jun 5.
J Med Chem. 2023.
PMID: 37276138
Review.
Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition.
Depetter Y, Geurs S, Vanden Bussche F, De Vreese R, Franceus J, Desmet T, De Wever O, D'hooghe M.
Depetter Y, et al. Among authors: geurs s.
Medchemcomm. 2018 May 18;9(6):1011-1016. doi: 10.1039/c8md00107c. eCollection 2018 Jun 1.
Medchemcomm. 2018.
PMID: 30108990
Free PMC article.
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Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy: screening, synthesis, and biological evaluation.
Geurs S, Clarisse D, Baele F, Franceus J, Desmet T, De Bosscher K, D'hooghe M.
Geurs S, et al.
Chem Commun (Camb). 2022 May 24;58(42):6239-6242. doi: 10.1039/d2cc01550a.
Chem Commun (Camb). 2022.
PMID: 35510683
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Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models.
Depetter Y, Geurs S, De Vreese R, Goethals S, Vandoorn E, Laevens A, Steenbrugge J, Meyer E, de Tullio P, Bracke M, D'hooghe M, De Wever O.
Depetter Y, et al. Among authors: geurs s.
Int J Cancer. 2019 Aug 1;145(3):735-747. doi: 10.1002/ijc.32169. Epub 2019 Feb 20.
Int J Cancer. 2019.
PMID: 30694564
Free article.
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CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy.
Franken A, Bila M, Mechels A, Kint S, Van Dessel J, Pomella V, Vanuytven S, Philips G, Bricard O, Xiong J, Boeckx B, Hatse S, Van Brussel T, Schepers R, Van Aerde C, Geurs S, Vandecaveye V, Hauben E, Vander Poorten V, Verbandt S, Vandereyken K, Qian J, Tejpar S, Voet T, Clement PM, Lambrechts D.
Franken A, et al. Among authors: geurs s.
Immunity. 2024 Mar 12;57(3):541-558.e7. doi: 10.1016/j.immuni.2024.02.007. Epub 2024 Mar 4.
Immunity. 2024.
PMID: 38442708
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Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: Possible implication for Alzheimer's disease.
Denechaud M, Geurs S, Comptdaer T, Bégard S, Garcia-Núñez A, Pechereau LA, Bouillet T, Vermeiren Y, De Deyn PP, Perbet R, Deramecourt V, Maurage CA, Vanderhaegen M, Vanuytven S, Lefebvre B, Bogaert E, Déglon N, Voet T, Colin M, Buée L, Dermaut B, Galas MC.
Denechaud M, et al. Among authors: geurs s.
Prog Neurobiol. 2023 Apr;223:102386. doi: 10.1016/j.pneurobio.2022.102386. Epub 2022 Dec 6.
Prog Neurobiol. 2023.
PMID: 36481386
Free article.
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A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain.
Davie K, Janssens J, Koldere D, De Waegeneer M, Pech U, Kreft Ł, Aibar S, Makhzami S, Christiaens V, Bravo González-Blas C, Poovathingal S, Hulselmans G, Spanier KI, Moerman T, Vanspauwen B, Geurs S, Voet T, Lammertyn J, Thienpont B, Liu S, Konstantinides N, Fiers M, Verstreken P, Aerts S.
Davie K, et al. Among authors: geurs s.
Cell. 2018 Aug 9;174(4):982-998.e20. doi: 10.1016/j.cell.2018.05.057. Epub 2018 Jun 18.
Cell. 2018.
PMID: 29909982
Free PMC article.
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TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis.
Van Nieuwenhuysen T, Naert T, Tran HT, Van Imschoot G, Geurs S, Sanders E, Creytens D, Van Roy F, Vleminckx K.
Van Nieuwenhuysen T, et al. Among authors: geurs s.
Oncoscience. 2015 May 19;2(5):555-66. doi: 10.18632/oncoscience.166. eCollection 2015.
Oncoscience. 2015.
PMID: 26097888
Free PMC article.
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