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Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.
Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y, Condello C, Grinberg LT, Seeley WW, Miller BL, Mok SA, Gestwicki JE, Cuervo AM, Luo W, Gan L. Wang C, et al. Among authors: gestwicki je. Nat Commun. 2022 Apr 12;13(1):1969. doi: 10.1038/s41467-022-29552-6. Nat Commun. 2022. PMID: 35413950 Free PMC article.
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. Min SW, et al. Nat Med. 2015 Oct;21(10):1154-62. doi: 10.1038/nm.3951. Epub 2015 Sep 21. Nat Med. 2015. PMID: 26390242 Free PMC article.
Therapeutic Strategies for Restoring Tau Homeostasis.
Young ZT, Mok SA, Gestwicki JE. Young ZT, et al. Among authors: gestwicki je. Cold Spring Harb Perspect Med. 2018 Jan 2;8(1):a024612. doi: 10.1101/cshperspect.a024612. Cold Spring Harb Perspect Med. 2018. PMID: 28159830 Free PMC article. Review.
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.
Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE. Mok SA, et al. Among authors: gestwicki je. Nat Struct Mol Biol. 2018 May;25(5):384-393. doi: 10.1038/s41594-018-0057-1. Epub 2018 Apr 30. Nat Struct Mol Biol. 2018. PMID: 29728653 Free PMC article.
Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.
Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE. Ravalin M, et al. Among authors: gestwicki je. Nat Chem Biol. 2019 Aug;15(8):786-794. doi: 10.1038/s41589-019-0322-6. Epub 2019 Jul 18. Nat Chem Biol. 2019. PMID: 31320752 Free PMC article.
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.
Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, Gestwicki JE, Xu K, Kosik KS, Gan L. Sohn PD, et al. Among authors: gestwicki je. Neuron. 2019 Nov 6;104(3):458-470.e5. doi: 10.1016/j.neuron.2019.08.008. Epub 2019 Sep 18. Neuron. 2019. PMID: 31542321 Free PMC article.
229 results