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Hsp70-Bag3 interactions regulate cancer-related signaling networks.
Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, Takayama S, Sherman MY. Colvin TA, et al. Among authors: gestwicki je. Cancer Res. 2014 Sep 1;74(17):4731-40. doi: 10.1158/0008-5472.CAN-14-0747. Epub 2014 Jul 3. Cancer Res. 2014. PMID: 24994713 Free PMC article.
Hsp70 protein complexes as drug targets.
Assimon VA, Gillies AT, Rauch JN, Gestwicki JE. Assimon VA, et al. Among authors: gestwicki je. Curr Pharm Des. 2013;19(3):404-17. doi: 10.2174/138161213804143699. Curr Pharm Des. 2013. PMID: 22920901 Free PMC article. Review.
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.
Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Miyata Y, et al. Among authors: gestwicki je. ACS Chem Neurosci. 2013 Jun 19;4(6):930-9. doi: 10.1021/cn300210g. Epub 2013 Mar 20. ACS Chem Neurosci. 2013. PMID: 23472668 Free PMC article.
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.
Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Abisambra J, et al. Among authors: gestwicki je. Biol Psychiatry. 2013 Sep 1;74(5):367-74. doi: 10.1016/j.biopsych.2013.02.027. Epub 2013 Apr 19. Biol Psychiatry. 2013. PMID: 23607970 Free PMC article.
Rehabilitating mutant GCase.
Rauch JN, Gestwicki JE. Rauch JN, et al. Among authors: gestwicki je. Chem Biol. 2014 Aug 14;21(8):919-20. doi: 10.1016/j.chembiol.2014.07.010. Chem Biol. 2014. PMID: 25126987
232 results