Gestwicki JE - Search Results

1

CSAR data set release 2012: ligands, affinities, complexes, and docking decoys.

Dunbar JB Jr, Smith RD, Damm-Ganamet KL, Ahmed A, Esposito EX, Delproposto J, Chinnaswamy K, Kang YN, Kubish G, Gestwicki JE, Stuckey JA, Carlson HA. Dunbar JB Jr, et al. Among authors: gestwicki je. J Chem Inf Model. 2013 Aug 26;53(8):1842-52. doi: 10.1021/ci4000486. Epub 2013 May 10. J Chem Inf Model. 2013. PMID: 23617227 Free PMC article.

2

An allosteric modulator of HIV-1 protease shows equipotent inhibition of wild-type and drug-resistant proteases.

Ung PM, Dunbar JB Jr, Gestwicki JE, Carlson HA. Ung PM, et al. Among authors: gestwicki je. J Med Chem. 2014 Aug 14;57(15):6468-78. doi: 10.1021/jm5008352. Epub 2014 Aug 1. J Med Chem. 2014. PMID: 25062388 Free PMC article.

3

Chemical probes that selectively recognize the earliest Aβ oligomers in complex mixtures.

Reinke AA, Ung PM, Quintero JJ, Carlson HA, Gestwicki JE. Reinke AA, et al. Among authors: gestwicki je. J Am Chem Soc. 2010 Dec 22;132(50):17655-7. doi: 10.1021/ja106291e. Epub 2010 Nov 24. J Am Chem Soc. 2010. PMID: 21105683 Free PMC article.

4

Identification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaK.

Ung PM, Thompson AD, Chang L, Gestwicki JE, Carlson HA. Ung PM, et al. Among authors: gestwicki je. PLoS Comput Biol. 2013;9(11):e1003279. doi: 10.1371/journal.pcbi.1003279. Epub 2013 Nov 21. PLoS Comput Biol. 2013. PMID: 24277995 Free PMC article.

5

A poke in the eye: inhibiting HIV-1 protease through its flap-recognition pocket.

Damm KL, Ung PM, Quintero JJ, Gestwicki JE, Carlson HA. Damm KL, et al. Among authors: gestwicki je. Biopolymers. 2008 Aug;89(8):643-52. doi: 10.1002/bip.20993. Biopolymers. 2008. PMID: 18381626 Free PMC article.

6

Clarifying allosteric control of flap conformations in the 1TW7 crystal structure of HIV-1 protease.

Lexa KW, Damm KL, Quintero JJ, Gestwicki JE, Carlson HA. Lexa KW, et al. Among authors: gestwicki je. Proteins. 2009 Mar;74(4):872-80. doi: 10.1002/prot.22195. Proteins. 2009. PMID: 18704936 Free PMC article.

7

Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK).

Chang L, Thompson AD, Ung P, Carlson HA, Gestwicki JE. Chang L, et al. Among authors: gestwicki je. J Biol Chem. 2010 Jul 9;285(28):21282-91. doi: 10.1074/jbc.M110.124149. Epub 2010 May 3. J Biol Chem. 2010. PMID: 20439464 Free PMC article.

8

Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.

Wisén S, Bertelsen EB, Thompson AD, Patury S, Ung P, Chang L, Evans CG, Walter GM, Wipf P, Carlson HA, Brodsky JL, Zuiderweg ER, Gestwicki JE. Wisén S, et al. Among authors: gestwicki je. ACS Chem Biol. 2010 Jun 18;5(6):611-22. doi: 10.1021/cb1000422. ACS Chem Biol. 2010. PMID: 20481474 Free PMC article.

9

Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism.

Chang L, Miyata Y, Ung PM, Bertelsen EB, McQuade TJ, Carlson HA, Zuiderweg ER, Gestwicki JE. Chang L, et al. Among authors: gestwicki je. Chem Biol. 2011 Feb 25;18(2):210-21. doi: 10.1016/j.chembiol.2010.12.010. Chem Biol. 2011. PMID: 21338918 Free PMC article.

10

Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods.

Makley LN, Johnson OT, Ghanakota P, Rauch JN, Osborn D, Wu TS, Cierpicki T, Carlson HA, Gestwicki JE. Makley LN, et al. Among authors: gestwicki je. Bioorg Med Chem. 2021 Mar 15;34:115990. doi: 10.1016/j.bmc.2020.115990. Epub 2021 Jan 24. Bioorg Med Chem. 2021. PMID: 33549906 Free PMC article.

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