Geschwindner S - Search Results

1

Application of optical biosensors in small-molecule screening activities.

Geschwindner S, Carlsson JF, Knecht W. Geschwindner S, et al. Sensors (Basel). 2012;12(4):4311-23. doi: 10.3390/s120404311. Epub 2012 Mar 28. Sensors (Basel). 2012. PMID: 22666031 Free PMC article. Review.

2

Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation.

Fjellström O, Deinum J, Sjögren T, Johansson C, Geschwindner S, Nerme V, Legnehed A, McPheat J, Olsson K, Bodin C, Paunovic A, Gustafsson D. Fjellström O, et al. Among authors: geschwindner s. J Biol Chem. 2013 Jan 11;288(2):873-85. doi: 10.1074/jbc.M112.371732. Epub 2012 Nov 15. J Biol Chem. 2013. PMID: 23155046 Free PMC article.

3

Development of a plate-based optical biosensor fragment screening methodology to identify phosphodiesterase 10A inhibitors.

Geschwindner S, Dekker N, Horsefield R, Tigerström A, Johansson P, Scott CW, Albert JS. Geschwindner S, et al. J Med Chem. 2013 Apr 25;56(8):3228-34. doi: 10.1021/jm301665y. Epub 2013 Apr 9. J Med Chem. 2013. PMID: 23509991

4

Biophysical methods in drug discovery from small molecule to pharmaceutical.

Holdgate G, Geschwindner S, Breeze A, Davies G, Colclough N, Temesi D, Ward L. Holdgate G, et al. Among authors: geschwindner s. Methods Mol Biol. 2013;1008:327-55. doi: 10.1007/978-1-62703-398-5_12. Methods Mol Biol. 2013. PMID: 23729258

5

Characterisation of de novo mutations in the C-terminal domain of proprotein convertase subtilisin/kexin type 9.

Geschwindner S, Andersson GM, Beisel HG, Breuer S, Hallberg C, Kihlberg BM, Lindqvist AM, O'Mahony G, Plowright AT, Raubacher F, Knecht W. Geschwindner S, et al. Protein Eng Des Sel. 2015 May;28(5):117-25. doi: 10.1093/protein/gzv008. Epub 2015 Mar 4. Protein Eng Des Sel. 2015. PMID: 25744035

6

Harnessing the Versatility of Optical Biosensors for Target-Based Small-Molecule Drug Discovery.

Kaminski T, Gunnarsson A, Geschwindner S. Kaminski T, et al. Among authors: geschwindner s. ACS Sens. 2017 Jan 27;2(1):10-15. doi: 10.1021/acssensors.6b00735. Epub 2016 Dec 23. ACS Sens. 2017. PMID: 28722441

7

Perspectives on optical biosensor utility in small-molecule screening.

Kaminski T, Geschwindner S. Kaminski T, et al. Among authors: geschwindner s. Expert Opin Drug Discov. 2017 Nov;12(11):1083-1086. doi: 10.1080/17460441.2017.1364727. Epub 2017 Aug 10. Expert Opin Drug Discov. 2017. PMID: 28777014 No abstract available.

8

Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR.

Gunnarsson A, Stubbs CJ, Rawlins PB, Taylor-Newman E, Lee WC, Geschwindner S, Hytönen V, Holdgate G, Jha R, Dahl G. Gunnarsson A, et al. Among authors: geschwindner s. SLAS Discov. 2021 Jun;26(5):730-739. doi: 10.1177/2472555220975358. Epub 2020 Dec 8. SLAS Discov. 2021. PMID: 33289457 Free article.

9

Drug discovery at the single molecule level: inhibition-in-solution assay of membrane-reconstituted β-secretase using single-molecule imaging.

Gunnarsson A, Snijder A, Hicks J, Gunnarsson J, Höök F, Geschwindner S. Gunnarsson A, et al. Among authors: geschwindner s. Anal Chem. 2015 Apr 21;87(8):4100-3. doi: 10.1021/acs.analchem.5b00740. Epub 2015 Apr 10. Anal Chem. 2015. PMID: 25855499

10

Avidity-Based Affinity Enhancement Using Nanoliposome-Amplified SPR Sensing Enables Low Picomolar Detection of Biologically Active Neuregulin 1.

Akkilic N, Liljeblad M, Blaho S, Hölttä M, Höök F, Geschwindner S. Akkilic N, et al. Among authors: geschwindner s. ACS Sens. 2019 Dec 27;4(12):3166-3174. doi: 10.1021/acssensors.9b01392. Epub 2019 Nov 27. ACS Sens. 2019. PMID: 31724395

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