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Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.
Bubenik M, Mader P, Mochirian P, Vallée F, Clark J, Truchon JF, Perryman AL, Pau V, Kurinov I, Zahn KE, Leclaire ME, Papp R, Mathieu MC, Hamel M, Duffy NM, Godbout C, Casas-Selves M, Falgueyret JP, Baruah PS, Nicolas O, Stocco R, Poirier H, Martino G, Fortin AB, Roulston A, Chefson A, Dorich S, St-Onge M, Patel P, Pellerin C, Ciblat S, Pinter T, Barabé F, El Bakkouri M, Parikh P, Gervais C, Sfeir A, Mamane Y, Morris SJ, Black WC, Sicheri F, Gallant M. Bubenik M, et al. Among authors: gervais c. J Med Chem. 2022 Oct 13;65(19):13198-13215. doi: 10.1021/acs.jmedchem.2c00998. Epub 2022 Sep 20. J Med Chem. 2022. PMID: 36126059 Free PMC article.
Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Álvarez-Quilón A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Muñoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. Álvarez-Quilón A, et al. Among authors: gervais c. Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8. Mol Cell. 2020. PMID: 32516598 Free PMC article.
Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates.
Stuible M, Schrag JD, Sheff J, Zoubchenok D, Lord-Dufour S, Cass B, L'Abbé D, Pelletier A, Rossotti MA, Tanha J, Gervais C, Maurice R, El Bakkouri M, Acchione M, Durocher Y. Stuible M, et al. Among authors: gervais c. Sci Rep. 2023 Oct 1;13(1):16498. doi: 10.1038/s41598-023-43661-2. Sci Rep. 2023. PMID: 37779126 Free PMC article.
A novel high throughput screening assay for HCV NS3 helicase activity.
Hicham Alaoui-Ismaili M, Gervais C, Brunette S, Gouin G, Hamel M, Rando RF, Bedard J. Hicham Alaoui-Ismaili M, et al. Among authors: gervais c. Antiviral Res. 2000 Jun;46(3):181-93. doi: 10.1016/s0166-3542(00)00085-1. Antiviral Res. 2000. PMID: 10867156
Parallel synthesis of isatin-based serine protease inhibitors.
Shuttleworth SJ, Nasturica D, Gervais C, Siddiqui MA, Rando RF, Lee N. Shuttleworth SJ, et al. Among authors: gervais c. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2501-4. doi: 10.1016/s0960-894x(00)00523-0. Bioorg Med Chem Lett. 2000. PMID: 11086715
Transient Gene Expression in Suspension HEK293-EBNA1 Cells.
L'Abbé D, Bisson L, Gervais C, Grazzini E, Durocher Y. L'Abbé D, et al. Among authors: gervais c. Methods Mol Biol. 2018;1850:1-16. doi: 10.1007/978-1-4939-8730-6_1. Methods Mol Biol. 2018. PMID: 30242676
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients.
Isho B, Abe KT, Zuo M, Jamal AJ, Rathod B, Wang JH, Li Z, Chao G, Rojas OL, Bang YM, Pu A, Christie-Holmes N, Gervais C, Ceccarelli D, Samavarchi-Tehrani P, Guvenc F, Budylowski P, Li A, Paterson A, Yue FY, Marin LM, Caldwell L, Wrana JL, Colwill K, Sicheri F, Mubareka S, Gray-Owen SD, Drews SJ, Siqueira WL, Barrios-Rodiles M, Ostrowski M, Rini JM, Durocher Y, McGeer AJ, Gommerman JL, Gingras AC. Isho B, et al. Among authors: gervais c. Sci Immunol. 2020 Oct 8;5(52):eabe5511. doi: 10.1126/sciimmunol.abe5511. Sci Immunol. 2020. PMID: 33033173 Free PMC article.
329 results