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Assessing Lymphatic Uptake of Lipids Using Magnetic Resonance Imaging: A Feasibility Study in Healthy Human Volunteers with Potential Application for Tracking Lymph Node Delivery of Drugs and Formulation Excipients.
Jewell A, Williams H, Hoad CL, Gellert PR, Ashford MB, Butler J, Stolnik S, Scurr D, Stocks MJ, Marciani L, Gowland PA, Gershkovich P. Jewell A, et al. Among authors: gershkovich p. Pharmaceutics. 2021 Aug 27;13(9):1343. doi: 10.3390/pharmaceutics13091343. Pharmaceutics. 2021. PMID: 34575420 Free PMC article.
Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates Micellar Solubilization In Vitro, but In Vivo Performance Remains Superior with Pure Sesame Oil Vehicle.
Feng W, Qin C, Cipolla E, Lee JB, Zgair A, Chu Y, Ortori CA, Stocks MJ, Constantinescu CS, Barrett DA, Fischer PM, Gershkovich P. Feng W, et al. Among authors: gershkovich p. Pharmaceutics. 2021 Aug 27;13(9):1349. doi: 10.3390/pharmaceutics13091349. Pharmaceutics. 2021. PMID: 34575426 Free PMC article.
Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol.
Feng W, Qin C, Abdelrazig S, Bai Z, Raji M, Darwish R, Chu Y, Ji L, Gray DA, Stocks MJ, Constantinescu CS, Barrett DA, Fischer PM, Gershkovich P. Feng W, et al. Among authors: gershkovich p. Int J Pharm. 2022 Aug 25;624:121947. doi: 10.1016/j.ijpharm.2022.121947. Epub 2022 Jun 23. Int J Pharm. 2022. PMID: 35753538 Free article.
Solid lipid nanoparticles self-assembled from spray dried microparticles.
Sanchez-Vazquez B, Lee JB, Strimaite M, Buanz A, Bailey R, Gershkovich P, Pasparakis G, Williams GR. Sanchez-Vazquez B, et al. Among authors: gershkovich p. Int J Pharm. 2019 Dec 15;572:118784. doi: 10.1016/j.ijpharm.2019.118784. Epub 2019 Oct 30. Int J Pharm. 2019. PMID: 31676339
Natural sesame oil is superior to pre-digested lipid formulations and purified triglycerides in promoting the intestinal lymphatic transport and systemic bioavailability of cannabidiol.
Feng W, Qin C, Chu Y, Berton M, Lee JB, Zgair A, Bettonte S, Stocks MJ, Constantinescu CS, Barrett DA, Fischer PM, Gershkovich P. Feng W, et al. Among authors: gershkovich p. Eur J Pharm Biopharm. 2021 May;162:43-49. doi: 10.1016/j.ejpb.2021.02.013. Epub 2021 Mar 5. Eur J Pharm Biopharm. 2021. PMID: 33677067
Oral administration of tipranavir with long-chain triglyceride results in moderate intestinal lymph targeting but no efficient delivery to HIV-1 reservoir in mesenteric lymph nodes.
Chu Y, Qin C, Feng W, Sheriston C, Jane Khor Y, Medrano-Padial C, Watson BE, Chan T, Ling B, Stocks MJ, Fischer PM, Gershkovich P. Chu Y, et al. Among authors: gershkovich p. Int J Pharm. 2021 Jun 1;602:120621. doi: 10.1016/j.ijpharm.2021.120621. Epub 2021 Apr 21. Int J Pharm. 2021. PMID: 33892057
109 results