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Is oral lipid-based delivery for drug targeting to the brain feasible?
Brookes A, Ji L, Bradshaw TD, Stocks M, Gray D, Butler J, Gershkovich P. Brookes A, et al. Among authors: gershkovich p. Eur J Pharm Biopharm. 2022 Mar;172:112-122. doi: 10.1016/j.ejpb.2022.02.004. Epub 2022 Feb 8. Eur J Pharm Biopharm. 2022. PMID: 35149190 Free article. Review.
Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system.
Lee JB, Zgair A, Malec J, Kim TH, Kim MG, Ali J, Qin C, Feng W, Chiang M, Gao X, Voronin G, Garces AE, Lau CL, Chan TH, Hume A, McIntosh TM, Soukarieh F, Al-Hayali M, Cipolla E, Collins HM, Heery DM, Shin BS, Yoo SD, Kagan L, Stocks MJ, Bradshaw TD, Fischer PM, Gershkovich P. Lee JB, et al. Among authors: gershkovich p. J Control Release. 2018 Sep 28;286:10-19. doi: 10.1016/j.jconrel.2018.07.022. Epub 2018 Jul 18. J Control Release. 2018. PMID: 30016732 Free PMC article.
Natural sesame oil is superior to pre-digested lipid formulations and purified triglycerides in promoting the intestinal lymphatic transport and systemic bioavailability of cannabidiol.
Feng W, Qin C, Chu Y, Berton M, Lee JB, Zgair A, Bettonte S, Stocks MJ, Constantinescu CS, Barrett DA, Fischer PM, Gershkovich P. Feng W, et al. Among authors: gershkovich p. Eur J Pharm Biopharm. 2021 May;162:43-49. doi: 10.1016/j.ejpb.2021.02.013. Epub 2021 Mar 5. Eur J Pharm Biopharm. 2021. PMID: 33677067
Oral administration of tipranavir with long-chain triglyceride results in moderate intestinal lymph targeting but no efficient delivery to HIV-1 reservoir in mesenteric lymph nodes.
Chu Y, Qin C, Feng W, Sheriston C, Jane Khor Y, Medrano-Padial C, Watson BE, Chan T, Ling B, Stocks MJ, Fischer PM, Gershkovich P. Chu Y, et al. Among authors: gershkovich p. Int J Pharm. 2021 Jun 1;602:120621. doi: 10.1016/j.ijpharm.2021.120621. Epub 2021 Apr 21. Int J Pharm. 2021. PMID: 33892057
Assessing Lymphatic Uptake of Lipids Using Magnetic Resonance Imaging: A Feasibility Study in Healthy Human Volunteers with Potential Application for Tracking Lymph Node Delivery of Drugs and Formulation Excipients.
Jewell A, Williams H, Hoad CL, Gellert PR, Ashford MB, Butler J, Stolnik S, Scurr D, Stocks MJ, Marciani L, Gowland PA, Gershkovich P. Jewell A, et al. Among authors: gershkovich p. Pharmaceutics. 2021 Aug 27;13(9):1343. doi: 10.3390/pharmaceutics13091343. Pharmaceutics. 2021. PMID: 34575420 Free PMC article.
Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol.
Feng W, Qin C, Abdelrazig S, Bai Z, Raji M, Darwish R, Chu Y, Ji L, Gray DA, Stocks MJ, Constantinescu CS, Barrett DA, Fischer PM, Gershkovich P. Feng W, et al. Among authors: gershkovich p. Int J Pharm. 2022 Aug 25;624:121947. doi: 10.1016/j.ijpharm.2022.121947. Epub 2022 Jun 23. Int J Pharm. 2022. PMID: 35753538 Free article.
Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer.
Garces AE, Al-Hayali M, Lee JB, Li J, Gershkovich P, Bradshaw TD, Stocks MJ. Garces AE, et al. Among authors: gershkovich p. ACS Med Chem Lett. 2019 Sep 27;11(3):316-321. doi: 10.1021/acsmedchemlett.9b00378. eCollection 2020 Mar 12. ACS Med Chem Lett. 2019. PMID: 32184963 Free PMC article.
109 results