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A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential.
Greenfield SA, Cole GM, Coen CW, Frautschy S, Singh RP, Mekkittikul M, Garcia-Ratés S, Morrill P, Hollings O, Passmore M, Hasan S, Carty N, Bison S, Piccoli L, Carletti R, Tacconi S, Chalidou A, Pedercini M, Kroecher T, Astner H, Gerrard PA. Greenfield SA, et al. Among authors: gerrard pa. Alzheimers Dement (N Y). 2022 Apr 5;8(1):e12274. doi: 10.1002/trc2.12274. eCollection 2022. Alzheimers Dement (N Y). 2022. PMID: 35415206 Free PMC article.
Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate.
Di Fabio R, Alvaro G, Braggio S, Carletti R, Gerrard PA, Griffante C, Marchioro C, Pozzan A, Melotto S, Poffe A, Piccoli L, Ratti E, Tranquillini E, Trower M, Spada S, Corsi M. Di Fabio R, et al. Among authors: gerrard pa. Bioorg Med Chem. 2013 Nov 1;21(21):6264-73. doi: 10.1016/j.bmc.2013.09.001. Epub 2013 Sep 11. Bioorg Med Chem. 2013. PMID: 24075145
Discovery and biological characterization of (2R,4S)-1'-acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4'-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) receptor antagonist clinical candidate.
Di Fabio R, Alvaro G, Griffante C, Pizzi DA, Donati D, Mattioli M, Cimarosti Z, Guercio G, Marchioro C, Provera S, Zonzini L, Montanari D, Melotto S, Gerrard PA, Trist DG, Ratti E, Corsi M. Di Fabio R, et al. Among authors: gerrard pa. J Med Chem. 2011 Feb 24;54(4):1071-9. doi: 10.1021/jm1013264. Epub 2011 Jan 13. J Med Chem. 2011. PMID: 21229983
Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist.
Di Fabio R, Griffante C, Alvaro G, Pentassuglia G, Pizzi DA, Donati D, Rossi T, Guercio G, Mattioli M, Cimarosti Z, Marchioro C, Provera S, Zonzini L, Montanari D, Melotto S, Gerrard PA, Trist DG, Ratti E, Corsi M. Di Fabio R, et al. Among authors: gerrard pa. J Med Chem. 2009 May 28;52(10):3238-47. doi: 10.1021/jm900023b. J Med Chem. 2009. PMID: 19388677
Effects of antidepressant drugs and GR 205171, an neurokinin-1 (NK1) receptor antagonist, on the response in the forced swim test and on monoamine extracellular levels in the frontal cortex of the mouse.
Zocchi A, Varnier G, Arban R, Griffante C, Zanetti L, Bettelini L, Marchi M, Gerrard PA, Corsi M. Zocchi A, et al. Among authors: gerrard pa. Neurosci Lett. 2003 Jul 17;345(2):73-6. doi: 10.1016/s0304-3940(03)00305-7. Neurosci Lett. 2003. PMID: 12821174
Anxiolytic profile of ropinirole in the rat, mouse and common marmoset.
Rogers DC, Costall B, Domeney AM, Gerrard PA, Greener M, Kelly ME, Hagan JJ, Hunter AJ. Rogers DC, et al. Among authors: gerrard pa. Psychopharmacology (Berl). 2000 Jul;151(1):91-7. doi: 10.1007/s002130000485. Psychopharmacology (Berl). 2000. PMID: 10958122
The effects of umespirone as a potential anxiolytic and antipsychotic agent.
Barnes NM, Costall B, Domeney AM, Gerrard PA, Kelly ME, Krähling H, Naylor RJ, Tomkins DM, Williams TJ. Barnes NM, et al. Among authors: gerrard pa. Pharmacol Biochem Behav. 1991 Sep;40(1):89-96. doi: 10.1016/0091-3057(91)90326-w. Pharmacol Biochem Behav. 1991. PMID: 1685786
The effect of ondansetron on cognitive performance in the marmoset.
Domeney AM, Costall B, Gerrard PA, Jones DN, Naylor RJ, Tyers MB. Domeney AM, et al. Among authors: gerrard pa. Pharmacol Biochem Behav. 1991 Jan;38(1):169-75. doi: 10.1016/0091-3057(91)90606-3. Pharmacol Biochem Behav. 1991. PMID: 1826787
14 results