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The 'Digital Twin' to enable the vision of precision cardiology.
Corral-Acero J, Margara F, Marciniak M, Rodero C, Loncaric F, Feng Y, Gilbert A, Fernandes JF, Bukhari HA, Wajdan A, Martinez MV, Santos MS, Shamohammdi M, Luo H, Westphal P, Leeson P, DiAchille P, Gurev V, Mayr M, Geris L, Pathmanathan P, Morrison T, Cornelussen R, Prinzen F, Delhaas T, Doltra A, Sitges M, Vigmond EJ, Zacur E, Grau V, Rodriguez B, Remme EW, Niederer S, Mortier P, McLeod K, Potse M, Pueyo E, Bueno-Orovio A, Lamata P. Corral-Acero J, et al. Among authors: geris l. Eur Heart J. 2020 Dec 21;41(48):4556-4564. doi: 10.1093/eurheartj/ehaa159. Eur Heart J. 2020. PMID: 32128588 Free PMC article.
Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility.
Musuamba FT, Skottheim Rusten I, Lesage R, Russo G, Bursi R, Emili L, Wangorsch G, Manolis E, Karlsson KE, Kulesza A, Courcelles E, Boissel JP, Rousseau CF, Voisin EM, Alessandrello R, Curado N, Dall'ara E, Rodriguez B, Pappalardo F, Geris L. Musuamba FT, et al. Among authors: geris l. CPT Pharmacometrics Syst Pharmacol. 2021 Aug;10(8):804-825. doi: 10.1002/psp4.12669. Epub 2021 Jul 13. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34102034 Free PMC article.
Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges.
Musuamba FT, Bursi R, Manolis E, Karlsson K, Kulesza A, Courcelles E, Boissel JP, Lesage R, Crozatier C, Voisin EM, Rousseau CF, Marchal T, Alessandrello R, Geris L. Musuamba FT, et al. Among authors: geris l. CPT Pharmacometrics Syst Pharmacol. 2020 Apr;9(4):195-197. doi: 10.1002/psp4.12504. Epub 2020 Apr 1. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32237207 Free PMC article. No abstract available.
Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of mesenchymal stromal cell (MSC)-derived soluble proteins and extracellular vesicles (EVs).
Gorgun C, Ceresa D, Lesage R, Villa F, Reverberi D, Balbi C, Santamaria S, Cortese K, Malatesta P, Geris L, Quarto R, Tasso R. Gorgun C, et al. Among authors: geris l. Biomaterials. 2021 Feb;269:120633. doi: 10.1016/j.biomaterials.2020.120633. Epub 2020 Dec 28. Biomaterials. 2021. PMID: 33453634 Free article.
Possible Contexts of Use for In Silico Trials Methodologies: A Consensus-Based Review.
Viceconti M, Emili L, Afshari P, Courcelles E, Curreli C, Famaey N, Geris L, Horner M, Jori MC, Kulesza A, Loewe A, Neidlin M, Reiterer M, Rousseau CF, Russo G, Sonntag SJ, Voisin EM, Pappalardo F. Viceconti M, et al. Among authors: geris l. IEEE J Biomed Health Inform. 2021 Oct;25(10):3977-3982. doi: 10.1109/JBHI.2021.3090469. Epub 2021 Oct 5. IEEE J Biomed Health Inform. 2021. PMID: 34161248 Free article. Review.
Toward A Regulatory Pathway for the Use of in Silico Trials in the CE Marking of Medical Devices.
Pappalardo F, Wilkinson J, Busquet F, Bril A, Palmer M, Walker B, Curreli C, Russo G, Marchal T, Toschi E, Alessandrello R, Costignola V, Klingmann I, Contin M, Staumont B, Woiczinski M, Kaddick C, Salvatore VD, Aldieri A, Geris L, Viceconti M. Pappalardo F, et al. Among authors: geris l. IEEE J Biomed Health Inform. 2022 Nov;26(11):5282-5286. doi: 10.1109/JBHI.2022.3198145. Epub 2022 Nov 10. IEEE J Biomed Health Inform. 2022. PMID: 35951559 Free article.
140 results