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Toll-like receptor 2, hyaluronan, and neutrophils play a key role in plaque erosion: the OPTICO-ACS study.
Meteva D, Vinci R, Seppelt C, Abdelwahed YS, Pedicino D, Nelles G, Skurk C, Haghikia A, Rauch-Kröhnert U, Gerhardt T, Straessler E, Zhao Y, Golla F, Joner M, Rai H, Kratzer A, Arnal HG, Liuzzo G, Klotsche J, Crea F, Landmesser U, Leistner DM, Kränkel N. Meteva D, et al. Among authors: gerhardt t. Eur Heart J. 2023 Oct 12;44(38):3892-3907. doi: 10.1093/eurheartj/ehad379. Eur Heart J. 2023. PMID: 37381760
Immune Mechanisms of Plaque Instability.
Gerhardt T, Haghikia A, Stapmanns P, Leistner DM. Gerhardt T, et al. Front Cardiovasc Med. 2022 Jan 11;8:797046. doi: 10.3389/fcvm.2021.797046. eCollection 2021. Front Cardiovasc Med. 2022. PMID: 35087883 Free PMC article. Review.
Culprit plaque morphology determines inflammatory risk and clinical outcomes in acute coronary syndrome.
Gerhardt T, Seppelt C, Abdelwahed YS, Meteva D, Wolfram C, Stapmanns P, Erbay A, Zanders L, Nelles G, Musfeld J, Sieronski L, Stähli BE, Montone RA, Vergallo R, Haghikia A, Skurk C, Knebel F, Dreger H, Trippel TD, Rai H, Joner M, Klotsche J, Libby P, Crea F, Kränkel N, Landmesser U, Leistner DM; OPTICO-ACS study group. Gerhardt T, et al. Eur Heart J. 2023 Oct 12;44(38):3911-3925. doi: 10.1093/eurheartj/ehad334. Eur Heart J. 2023. PMID: 37381774
Spotty calcium deposits within acute coronary syndrome (ACS)-causing culprit lesions impact inflammatory vessel-wall interactions and are associated with higher cardiovascular event rates at one year follow-up: Results from the prospective translational OPTICO-ACS study program.
Nelles G, Abdelwahed YS, Alyaqoob A, Seppelt C, Stähli BE, Meteva D, Kränkel N, Haghikia A, Skurk C, Dreger H, Knebel F, Trippel TD, Krisper M, Sieronski L, Gerhardt T, Zanders L, Klotsche J, Landmesser U, Joner M, Leistner DM. Nelles G, et al. Among authors: gerhardt t. Atherosclerosis. 2023 Nov;385:117284. doi: 10.1016/j.atherosclerosis.2023.117284. Epub 2023 Sep 15. Atherosclerosis. 2023. PMID: 37871405
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100-Reactive CD4+ T-Regulatory Cells.
Wolf D, Gerhardt T, Winkels H, Michel NA, Pramod AB, Ghosheh Y, Brunel S, Buscher K, Miller J, McArdle S, Baas L, Kobiyama K, Vassallo M, Ehinger E, Dileepan T, Ali A, Schell M, Mikulski Z, Sidler D, Kimura T, Sheng X, Horstmann H, Hansen S, Mitre LS, Stachon P, Hilgendorf I, Gaddis DE, Hedrick C, Benedict CA, Peters B, Zirlik A, Sette A, Ley K. Wolf D, et al. Among authors: gerhardt t. Circulation. 2020 Sep 29;142(13):1279-1293. doi: 10.1161/CIRCULATIONAHA.119.042863. Epub 2020 Jul 24. Circulation. 2020. PMID: 32703007 Free PMC article.
CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis.
Li J, McArdle S, Gholami A, Kimura T, Wolf D, Gerhardt T, Miller J, Weber C, Ley K. Li J, et al. Among authors: gerhardt t. Circ Res. 2016 May 13;118(10):1540-52. doi: 10.1161/CIRCRESAHA.116.308648. Epub 2016 Mar 28. Circ Res. 2016. PMID: 27021296 Free PMC article.
Cholesterol crystals at the culprit lesion in patients with acute coronary syndrome are associated with worse cardiovascular outcomes at two years follow up - results from the translational OPTICO-ACS study program.
Nelles G, Abdelwahed YS, Seppelt C, Meteva D, Stähli BE, Rai H, Seegers LM, Sieronski L, Musfeldt J, Gerhardt T, Riedel M, Skurk C, Haghikia A, Sinning D, Dreger H, Knebel F, Trippel TD, Krisper M, Klotsche J, Joner M, Landmesser U, Leistner DM. Nelles G, et al. Among authors: gerhardt t. Int J Cardiol. 2024 Mar 15;399:131665. doi: 10.1016/j.ijcard.2023.131665. Epub 2023 Dec 22. Int J Cardiol. 2024. PMID: 38141724
148 results