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Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner.
Schumann T, Ramon SC, Schubert N, Mayo MA, Hega M, Maser KI, Ada SR, Sydow L, Hajikazemi M, Badstübner M, Müller P, Ge Y, Shakeri F, Buness A, Rupf B, Lienenklaus S, Utess B, Muhandes L, Haase M, Rupp L, Schmitz M, Gramberg T, Manel N, Hartmann G, Zillinger T, Kato H, Bauer S, Gerbaulet A, Paeschke K, Roers A, Behrendt R. Schumann T, et al. Among authors: gerbaulet a. J Exp Med. 2023 Jan 2;220(1):e20220829. doi: 10.1084/jem.20220829. Epub 2022 Nov 8. J Exp Med. 2023. PMID: 36346347 Free PMC article.
Mast cell apoptosis.
Gerbaulet A, Hartmann K, Mekori YA. Gerbaulet A, et al. Methods Mol Biol. 2006;315:407-23. doi: 10.1385/1-59259-967-2:407. Methods Mol Biol. 2006. PMID: 16110173
Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response.
Behrendt R, Schumann T, Gerbaulet A, Nguyen LA, Schubert N, Alexopoulou D, Berka U, Lienenklaus S, Peschke K, Gibbert K, Wittmann S, Lindemann D, Weiss S, Dahl A, Naumann R, Dittmer U, Kim B, Mueller W, Gramberg T, Roers A. Behrendt R, et al. Among authors: gerbaulet a. Cell Rep. 2013 Aug 29;4(4):689-96. doi: 10.1016/j.celrep.2013.07.037. Epub 2013 Aug 22. Cell Rep. 2013. PMID: 23972988 Free PMC article.
Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity.
Peschke K, Achleitner M, Frenzel K, Gerbaulet A, Ada SR, Zeller N, Lienenklaus S, Lesche M, Poulet C, Naumann R, Dahl A, Ravens U, Günther C, Müller W, Knobeloch KP, Prinz M, Roers A, Behrendt R. Peschke K, et al. Among authors: gerbaulet a. J Immunol. 2016 Sep 15;197(6):2157-66. doi: 10.4049/jimmunol.1600722. Epub 2016 Aug 10. J Immunol. 2016. PMID: 27511730
Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.
Achleitner M, Kleefisch M, Hennig A, Peschke K, Polikarpova A, Oertel R, Gabriel B, Schulze L, Lindeman D, Gerbaulet A, Fiebig U, Lee-Kirsch MA, Roers A, Behrendt R. Achleitner M, et al. Among authors: gerbaulet a. J Immunol. 2017 Oct 1;199(7):2261-2269. doi: 10.4049/jimmunol.1700714. Epub 2017 Aug 23. J Immunol. 2017. PMID: 28835460
144 results