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Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.
Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, Hung MD, Vidal R, Fuentealba M, Miedema T, Duran-Aniotz C, Diaz J, Ibaceta-Gonzalez C, Sabusap CM, Bermedo-Garcia F, Mujica P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi SP, Lipton SA, Kennedy BK, Henriquez JP, Cárdenas JC, Plate L, Palacios AG, Hetz C. Cabral-Miranda F, et al. Among authors: gerakis y. EMBO J. 2022 Nov 17;41(22):e111952. doi: 10.15252/embj.2022111952. Epub 2022 Oct 31. EMBO J. 2022. PMID: 36314651 Free PMC article.
The UFMylation System in Proteostasis and Beyond.
Gerakis Y, Quintero M, Li H, Hetz C. Gerakis Y, et al. Trends Cell Biol. 2019 Dec;29(12):974-986. doi: 10.1016/j.tcb.2019.09.005. Epub 2019 Nov 6. Trends Cell Biol. 2019. PMID: 31703843 Free PMC article. Review.
The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis.
Duran-Aniotz C, Poblete N, Rivera-Krstulovic C, Ardiles ÁO, Díaz-Hung ML, Tamburini G, Sabusap CMP, Gerakis Y, Cabral-Miranda F, Diaz J, Fuentealba M, Arriagada D, Muñoz E, Espinoza S, Martinez G, Quiroz G, Sardi P, Medinas DB, Contreras D, Piña R, Lourenco MV, Ribeiro FC, Ferreira ST, Rozas C, Morales B, Plate L, Gonzalez-Billault C, Palacios AG, Hetz C. Duran-Aniotz C, et al. Among authors: gerakis y. Mol Ther. 2023 Jul 5;31(7):2240-2256. doi: 10.1016/j.ymthe.2023.03.028. Epub 2023 Apr 4. Mol Ther. 2023. PMID: 37016577