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An enolase inhibitor for the targeted treatment of ENO1-deleted cancers.
Lin YH, Satani N, Hammoudi N, Yan VC, Barekatain Y, Khadka S, Ackroyd JJ, Georgiou DK, Pham CD, Arthur K, Maxwell D, Peng Z, Leonard PG, Czako B, Pisaneschi F, Mandal P, Sun Y, Zielinski R, Pando SC, Wang X, Tran T, Xu Q, Wu Q, Jiang Y, Kang Z, Asara JM, Priebe W, Bornmann W, Marszalek JR, DePinho RA, Muller FL. Lin YH, et al. Among authors: georgiou dk. Nat Metab. 2020 Dec;2(12):1413-1426. doi: 10.1038/s42255-020-00313-3. Epub 2020 Nov 23. Nat Metab. 2020. PMID: 33230295 Free PMC article.
Bioreducible Phosphonoamidate Pro-drug Inhibitor of Enolase: Proof of Concept Study.
Yan VC, Yang KL, Ballato ES, Khadka S, Shrestha P, Arthur K, Georgiou DK, Washington M, Tran T, Poral AH, Pham CD, Yan MJ, Muller FL. Yan VC, et al. Among authors: georgiou dk. ACS Med Chem Lett. 2020 Jun 22;11(7):1484-1489. doi: 10.1021/acsmedchemlett.0c00203. eCollection 2020 Jul 9. ACS Med Chem Lett. 2020. PMID: 32676158 Free PMC article.
Author Correction: An enolase inhibitor for the targeted treatment of ENO1-deleted cancers.
Lin YH, Satani N, Hammoudi N, Yan VC, Barekatain Y, Khadka S, Ackroyd JJ, Georgiou DK, Pham CD, Arthur K, Maxwell D, Peng Z, Leonard PG, Czako B, Pisaneschi F, Mandal P, Sun Y, Zielinski R, Pando SC, Wang X, Tran T, Xu Q, Wu Q, Jiang Y, Kang Z, Asara JM, Priebe W, Bornmann W, Marszalek JR, DePinho RA, Muller FL. Lin YH, et al. Among authors: georgiou dk. Nat Metab. 2021 Jan;3(1):122. doi: 10.1038/s42255-020-00335-x. Nat Metab. 2021. PMID: 33340032 No abstract available.
Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma.
Khadka S, Arthur K, Barekatain Y, Behr E, Washington M, Ackroyd J, Crowley K, Suriyamongkol P, Lin YH, Pham CD, Zielinski R, Trujillo M, Galligan J, Georgiou DK, Asara J, Muller F. Khadka S, et al. Among authors: georgiou dk. Cancer Metab. 2021 Jun 25;9(1):27. doi: 10.1186/s40170-021-00259-4. Cancer Metab. 2021. PMID: 34172075 Free PMC article.
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine.
Barekatain Y, Ackroyd JJ, Yan VC, Khadka S, Wang L, Chen KC, Poral AH, Tran T, Georgiou DK, Arthur K, Lin YH, Satani N, Ballato ES, Behr EI, deCarvalho AC, Verhaak RGW, de Groot J, Huse JT, Asara JM, Kalluri R, Muller FL. Barekatain Y, et al. Among authors: georgiou dk. Nat Commun. 2021 Jul 9;12(1):4228. doi: 10.1038/s41467-021-24240-3. Nat Commun. 2021. PMID: 34244484 Free PMC article.
Prodrugs of a 1-Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers.
Yan VC, Pham CD, Ballato ES, Yang KL, Arthur K, Khadka S, Barekatain Y, Shrestha P, Tran T, Poral AH, Washington M, Raghavan S, Czako B, Pisaneschi F, Lin YH, Satani N, Hammoudi N, Ackroyd JJ, Georgiou DK, Millward SW, Muller FL. Yan VC, et al. Among authors: georgiou dk. J Med Chem. 2022 Oct 27;65(20):13813-13832. doi: 10.1021/acs.jmedchem.2c01039. Epub 2022 Oct 17. J Med Chem. 2022. PMID: 36251833 Free PMC article.
Comparative Pharmacology of a Bis-Pivaloyloxymethyl Phosphonate Prodrug Inhibitor of Enolase after Oral and Parenteral Administration.
Yan VC, Barekatain Y, Lin YH, Satani N, Hammoudi N, Arthur K, Georgiou DK, Jiang Y, Sun Y, Marszalek JR, Millward SW, Muller FL. Yan VC, et al. Among authors: georgiou dk. ACS Pharmacol Transl Sci. 2023 Jan 6;6(2):245-252. doi: 10.1021/acsptsci.2c00216. eCollection 2023 Feb 10. ACS Pharmacol Transl Sci. 2023. PMID: 36798479 Free PMC article.
AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation.
Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL. Lanner JT, et al. Among authors: georgiou dk. Nat Med. 2012 Jan 8;18(2):244-51. doi: 10.1038/nm.2598. Nat Med. 2012. PMID: 22231556 Free PMC article.
A chemical chaperone improves muscle function in mice with a RyR1 mutation.
Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SL. Lee CS, et al. Among authors: georgiou dk. Nat Commun. 2017 Mar 24;8:14659. doi: 10.1038/ncomms14659. Nat Commun. 2017. PMID: 28337975 Free PMC article.
24 results