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A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies.
Flisikowska T, Egli J, Flisikowski K, Stumbaum M, Küng E, Ebeling M, Schmucki R, Georges G, Singer T, Kurome M, Kessler B, Zakhartchenko V, Wolf E, Weber F, Schnieke A, Iglesias A. Flisikowska T, et al. Among authors: georges g. Nat Biomed Eng. 2022 Nov;6(11):1248-1256. doi: 10.1038/s41551-022-00921-2. Epub 2022 Sep 22. Nat Biomed Eng. 2022. PMID: 36138193 Free PMC article.
MoFvAb: Modeling the Fv region of antibodies.
Bujotzek A, Fuchs A, Qu C, Benz J, Klostermann S, Antes I, Georges G. Bujotzek A, et al. Among authors: georges g. MAbs. 2015;7(5):838-52. doi: 10.1080/19420862.2015.1068492. MAbs. 2015. PMID: 26176812 Free PMC article.
Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies.
Dickopf S, Buldun C, Vasic V, Georges G, Hage C, Mayer K, Forster M, Wessels U, Stubenrauch KG, Benz J, Ehler A, Lauer ME, Ringler P, Kobold S, Endres S, Klein C, Brinkmann U. Dickopf S, et al. Among authors: georges g. Biol Chem. 2022 Jan 20;403(5-6):495-508. doi: 10.1515/hsz-2021-0401. Print 2022 Apr 26. Biol Chem. 2022. PMID: 35073465 Free PMC article.
The Contorsbody, an antibody format for agonism: Design, structure, and function.
Georges GJ, Dengl S, Bujotzek A, Hesse F, Fischer JAA, Gärtner A, Benz J, Lauer ME, Ringler P, Stahlberg H, Plath F, Brinkmann U, Imhof-Jung S. Georges GJ, et al. Comput Struct Biotechnol J. 2020 May 14;18:1210-1220. doi: 10.1016/j.csbj.2020.05.007. eCollection 2020. Comput Struct Biotechnol J. 2020. PMID: 32542107 Free PMC article.
Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats.
Fernández-Quintero ML, Quoika PK, Wedl FS, Seidler CA, Kroell KB, Loeffler JR, Pomarici ND, Hoerschinger VJ, Bujotzek A, Georges G, Kettenberger H, Liedl KR. Fernández-Quintero ML, et al. Among authors: georges g. Front Mol Biosci. 2022 Jan 26;9:812750. doi: 10.3389/fmolb.2022.812750. eCollection 2022. Front Mol Biosci. 2022. PMID: 35155578 Free PMC article.
Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies.
Schaefer W, Regula JT, Bähner M, Schanzer J, Croasdale R, Dürr H, Gassner C, Georges G, Kettenberger H, Imhof-Jung S, Schwaiger M, Stubenrauch KG, Sustmann C, Thomas M, Scheuer W, Klein C. Schaefer W, et al. Among authors: georges g. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11187-92. doi: 10.1073/pnas.1019002108. Epub 2011 Jun 20. Proc Natl Acad Sci U S A. 2011. PMID: 21690412 Free PMC article.
276 results