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Page 1
Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia.
Higgins MA, Marcin LR, Christopher Zusi F, Gentles R, Ding M, Pearce BC, Easton A, Kostich WA, Seager MA, Bourin C, Bristow LJ, Johnson KA, Miller R, Hogan J, Whiterock V, Gulianello M, Ferrante M, Huang Y, Hendricson A, Alt A, Macor JE, Bronson JJ. Higgins MA, et al. Among authors: gentles r. Bioorg Med Chem. 2017 Jan 15;25(2):496-513. doi: 10.1016/j.bmc.2016.11.018. Epub 2016 Nov 14. Bioorg Med Chem. 2017. PMID: 27914948
Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1.
Souers AJ, Wodka D, Gao J, Lewis JC, Vasudevan A, Gentles R, Brodjian S, Dayton B, Ogiela CA, Fry D, Hernandez LE, Marsh KC, Collins CA, Kym PR. Souers AJ, et al. Among authors: gentles r. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. doi: 10.1016/j.bmcl.2004.07.032. Bioorg Med Chem Lett. 2004. PMID: 15341942
Ligand-induced changes in hepatitis C virus NS5B polymerase structure.
Rigat K, Wang Y, Hudyma TW, Ding M, Zheng X, Gentles RG, Beno BR, Gao M, Roberts SB. Rigat K, et al. Among authors: gentles rg. Antiviral Res. 2010 Nov;88(2):197-206. doi: 10.1016/j.antiviral.2010.08.014. Epub 2010 Sep 9. Antiviral Res. 2010. PMID: 20813137
Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
Gentles RG, Sheriff S, Beno BR, Wan C, Kish K, Ding M, Zheng X, Chupak L, Poss MA, Witmer MR, Morin P, Wang YK, Rigat K, Lemm J, Voss S, Liu M, Pelosi L, Roberts SB, Gao M, Kadow JF. Gentles RG, et al. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2212-5. doi: 10.1016/j.bmcl.2011.03.011. Epub 2011 Mar 6. Bioorg Med Chem Lett. 2011. PMID: 21441029
Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Zheng X, Hudyma TW, Martin SW, Bergstrom C, Ding M, He F, Romine J, Poss MA, Kadow JF, Chang CH, Wan J, Witmer MR, Morin P, Camac DM, Sheriff S, Beno BR, Rigat KL, Wang YK, Fridell R, Lemm J, Qiu D, Liu M, Voss S, Pelosi L, Roberts SB, Gao M, Knipe J, Gentles RG. Zheng X, et al. Among authors: gentles rg. Bioorg Med Chem Lett. 2011 May 15;21(10):2925-9. doi: 10.1016/j.bmcl.2011.03.067. Epub 2011 Mar 23. Bioorg Med Chem Lett. 2011. PMID: 21486696
The synthesis of novel heteroaryl-fused 7,8,9,10-tetrahydro-6H-azepino[1,2-a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Effective inhibitors of HCV NS5B polymerase.
Ding M, He F, Poss MA, Rigat KL, Wang YK, Roberts SB, Qiu D, Fridell RA, Gao M, Gentles RG. Ding M, et al. Org Biomol Chem. 2011 Oct 7;9(19):6654-62. doi: 10.1039/c1ob05525a. Epub 2011 Jul 28. Org Biomol Chem. 2011. PMID: 21800000
Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase.
Ding M, He F, Hudyma TW, Zheng X, Poss MA, Kadow JF, Beno BR, Rigat KL, Wang YK, Fridell RA, Lemm JA, Qiu D, Liu M, Voss S, Pelosi LA, Roberts SB, Gao M, Knipe J, Gentles RG. Ding M, et al. Among authors: gentles rg. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2866-71. doi: 10.1016/j.bmcl.2012.02.063. Epub 2012 Mar 1. Bioorg Med Chem Lett. 2012. PMID: 22424979
33 results