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Preclinical development of a miR-132 inhibitor for heart failure treatment.
Foinquinos A, Batkai S, Genschel C, Viereck J, Rump S, Gyöngyösi M, Traxler D, Riesenhuber M, Spannbauer A, Lukovic D, Weber N, Zlabinger K, Hašimbegović E, Winkler J, Fiedler J, Dangwal S, Fischer M, de la Roche J, Wojciechowski D, Kraft T, Garamvölgyi R, Neitzel S, Chatterjee S, Yin X, Bär C, Mayr M, Xiao K, Thum T. Foinquinos A, et al. Among authors: genschel c. Nat Commun. 2020 Jan 31;11(1):633. doi: 10.1038/s41467-020-14349-2. Nat Commun. 2020. PMID: 32005803 Free PMC article.
CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure.
Batkai S, Genschel C, Viereck J, Rump S, Bär C, Borchert T, Traxler D, Riesenhuber M, Spannbauer A, Lukovic D, Zlabinger K, Hašimbegović E, Winkler J, Garamvölgyi R, Neitzel S, Gyöngyösi M, Thum T. Batkai S, et al. Among authors: genschel c. Eur Heart J. 2021 Jan 7;42(2):192-201. doi: 10.1093/eurheartj/ehaa791. Eur Heart J. 2021. PMID: 33089304 Free PMC article.
Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study.
Täubel J, Hauke W, Rump S, Viereck J, Batkai S, Poetzsch J, Rode L, Weigt H, Genschel C, Lorch U, Theek C, Levin AA, Bauersachs J, Solomon SD, Thum T. Täubel J, et al. Among authors: genschel c. Eur Heart J. 2021 Jan 7;42(2):178-188. doi: 10.1093/eurheartj/ehaa898. Eur Heart J. 2021. PMID: 33245749 Free PMC article. Clinical Trial.
Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis.
Kenneweg F, Bang C, Xiao K, Boulanger CM, Loyer X, Mazlan S, Schroen B, Hermans-Beijnsberger S, Foinquinos A, Hirt MN, Eschenhagen T, Funcke S, Stojanovic S, Genschel C, Schimmel K, Just A, Pfanne A, Scherf K, Dehmel S, Raemon-Buettner SM, Fiedler J, Thum T. Kenneweg F, et al. Among authors: genschel c. Mol Ther Nucleic Acids. 2019 Dec 6;18:363-374. doi: 10.1016/j.omtn.2019.09.003. Epub 2019 Sep 13. Mol Ther Nucleic Acids. 2019. PMID: 31634682 Free PMC article.
Hypoxia-induced long non-coding RNA Malat1 is dispensable for renal ischemia/reperfusion-injury.
Kölling M, Genschel C, Kaucsar T, Hübner A, Rong S, Schmitt R, Sörensen-Zender I, Haddad G, Kistler A, Seeger H, Kielstein JT, Fliser D, Haller H, Wüthrich R, Zörnig M, Thum T, Lorenzen J. Kölling M, et al. Among authors: genschel c. Sci Rep. 2018 Feb 21;8(1):3438. doi: 10.1038/s41598-018-21720-3. Sci Rep. 2018. PMID: 29467431 Free PMC article.