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TIM-3, LAG-3, or 2B4 gene disruptions increase the anti-tumor response of engineered T cells.
Cianciotti BC, Magnani ZI, Ugolini A, Camisa B, Merelli I, Vavassori V, Potenza A, Imparato A, Manfredi F, Abbati D, Perani L, Spinelli A, Shifrut E, Ciceri F, Vago L, Di Micco R, Naldini L, Genovese P, Ruggiero E, Bonini C. Cianciotti BC, et al. Among authors: genovese p. Front Immunol. 2024 Feb 29;15:1315283. doi: 10.3389/fimmu.2024.1315283. eCollection 2024. Front Immunol. 2024. PMID: 38510235 Free PMC article.
Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency.
Castiello MC, Brandas C, Ferrari S, Porcellini S, Sacchetti N, Canarutto D, Draghici E, Merelli I, Barcella M, Pelosi G, Vavassori V, Varesi A, Jacob A, Scala S, Basso Ricci L, Paulis M, Strina D, Di Verniere M, Sergi Sergi L, Serafini M, Holland SM, Bergerson JRE, De Ravin SS, Malech HL, Pala F, Bosticardo M, Brombin C, Cugnata F, Calzoni E, Crooks GM, Notarangelo LD, Genovese P, Naldini L, Villa A. Castiello MC, et al. Among authors: genovese p. Sci Transl Med. 2024 Feb 7;16(733):eadh8162. doi: 10.1126/scitranslmed.adh8162. Epub 2024 Feb 7. Sci Transl Med. 2024. PMID: 38324638
Consensus-based guidelines for the provision of palliative and end-of-life care for people living with epidermolysis bullosa.
Popenhagen MP, Genovese P, Blishen M, Rajapakse D, Diem A, King A, Chan J, Pellicer Arasa E, Baird S, Ferreira da Rocha AC, Stitt G, Badger K, Zmazek V, Ambreen F, Mackenzie C, Price H, Roberts T, Moore Z, Patton D, Murphy P, Mayre-Chilton K. Popenhagen MP, et al. Among authors: genovese p. Orphanet J Rare Dis. 2023 Sep 4;18(1):268. doi: 10.1186/s13023-023-02870-8. Orphanet J Rare Dis. 2023. PMID: 37667330 Free PMC article.
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia.
Casirati G, Cosentino A, Mucci A, Salah Mahmoud M, Ugarte Zabala I, Zeng J, Ficarro SB, Klatt D, Brendel C, Rambaldi A, Ritz J, Marto JA, Pellin D, Bauer DE, Armstrong SA, Genovese P. Casirati G, et al. Among authors: genovese p. Nature. 2023 Sep;621(7978):404-414. doi: 10.1038/s41586-023-06496-5. Epub 2023 Aug 30. Nature. 2023. PMID: 37648862 Free PMC article.
Base Editing of Human Hematopoietic Stem Cells.
Zeng J, Casirati G, Nguyen MA, Genovese P, Bauer DE. Zeng J, et al. Among authors: genovese p. Methods Mol Biol. 2023;2606:43-62. doi: 10.1007/978-1-0716-2879-9_5. Methods Mol Biol. 2023. PMID: 36592307
79 results