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Page 1
Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.
Jung SM, Hung CM, Hildebrand SR, Sanchez-Gurmaches J, Martinez-Pastor B, Gengatharan JM, Wallace M, Mukhopadhyay D, Martinez Calejman C, Luciano AK, Hsiao WY, Tang Y, Li H, Daniels DL, Mostoslavsky R, Metallo CM, Guertin DA. Jung SM, et al. Among authors: gengatharan jm. Mol Cell. 2019 Aug 22;75(4):807-822.e8. doi: 10.1016/j.molcel.2019.07.023. Mol Cell. 2019. PMID: 31442424 Free PMC article.
Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues.
Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM. Wallace M, et al. Among authors: gengatharan jm. Nat Chem Biol. 2018 Nov;14(11):1021-1031. doi: 10.1038/s41589-018-0132-2. Epub 2018 Oct 16. Nat Chem Biol. 2018. PMID: 30327559 Free PMC article.
Serine restriction alters sphingolipid diversity to constrain tumour growth.
Muthusamy T, Cordes T, Handzlik MK, You L, Lim EW, Gengatharan J, Pinto AFM, Badur MG, Kolar MJ, Wallace M, Saghatelian A, Metallo CM. Muthusamy T, et al. Nature. 2020 Oct;586(7831):790-795. doi: 10.1038/s41586-020-2609-x. Epub 2020 Aug 12. Nature. 2020. PMID: 32788725 Free PMC article.
Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso-heptadecanoic Acid Are Inversely Associated With Liver Fat in Children.
Sawh MC, Wallace M, Shapiro E, Goyal NP, Newton KP, Yu EL, Bross C, Durelle J, Knott C, Gangoiti JA, Barshop BA, Gengatharan JM, Meurs N, Schlein A, Middleton MS, Sirlin CB, Metallo CM, Schwimmer JB. Sawh MC, et al. Among authors: gengatharan jm. J Pediatr Gastroenterol Nutr. 2021 Apr 1;72(4):e90-e96. doi: 10.1097/MPG.0000000000003040. J Pediatr Gastroenterol Nutr. 2021. PMID: 33399331 Free PMC article.
Acetate reprograms gut microbiota during alcohol consumption.
Martino C, Zaramela LS, Gao B, Embree M, Tarasova J, Parker SJ, Wang Y, Chu H, Chen P, Lee KC, Galzerani DD, Gengatharan JM, Lekbua A, Neal M, Knight R, Tsukamoto H, Metallo CM, Schnabl B, Zengler K. Martino C, et al. Among authors: gengatharan jm. Nat Commun. 2022 Aug 8;13(1):4630. doi: 10.1038/s41467-022-31973-2. Nat Commun. 2022. PMID: 35941112 Free PMC article.
Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.
Handzlik MK, Gengatharan JM, Frizzi KE, McGregor GH, Martino C, Rahman G, Gonzalez A, Moreno AM, Green CR, Guernsey LS, Lin T, Tseng P, Ideguchi Y, Fallon RJ, Chaix A, Panda S, Mali P, Wallace M, Knight R, Gantner ML, Calcutt NA, Metallo CM. Handzlik MK, et al. Among authors: gengatharan jm. Nature. 2023 Feb;614(7946):118-124. doi: 10.1038/s41586-022-05637-6. Epub 2023 Jan 25. Nature. 2023. PMID: 36697822 Free PMC article.