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Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model.
Cell Rep Med. 2021 Oct 19;2(10):100420. doi: 10.1016/j.xcrm.2021.100420. Epub 2021 Sep 28.
Cell Rep Med. 2021.
PMID: 34604818
Free PMC article.
Novel IFN-γ ELISpot reveals robust T cell responses elicited after influenza nucleoprotein DNA vaccination in New Zealand White rabbits.
Yung BS, Pugh H, Generotti AA, Phanhthilath N, Schultheis K, Muthumani K, Broderick KE, Smith TRF.
Yung BS, et al. Among authors: generotti aa.
Vaccine. 2019 Feb 8;37(7):903-909. doi: 10.1016/j.vaccine.2019.01.006. Epub 2019 Jan 17.
Vaccine. 2019.
PMID: 30661837
Free article.
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Immunogenicity of a DNA vaccine candidate for COVID-19.
Smith TRF, Patel A, Ramos S, Elwood D, Zhu X, Yan J, Gary EN, Walker SN, Schultheis K, Purwar M, Xu Z, Walters J, Bhojnagarwala P, Yang M, Chokkalingam N, Pezzoli P, Parzych E, Reuschel EL, Doan A, Tursi N, Vasquez M, Choi J, Tello-Ruiz E, Maricic I, Bah MA, Wu Y, Amante D, Park DH, Dia Y, Ali AR, Zaidi FI, Generotti A, Kim KY, Herring TA, Reeder S, Andrade VM, Buttigieg K, Zhao G, Wu JM, Li D, Bao L, Liu J, Deng W, Qin C, Brown AS, Khoshnejad M, Wang N, Chu J, Wrapp D, McLellan JS, Muthumani K, Wang B, Carroll MW, Kim JJ, Boyer J, Kulp DW, Humeau LMPF, Weiner DB, Broderick KE.
Smith TRF, et al. Among authors: generotti a.
Nat Commun. 2020 May 20;11(1):2601. doi: 10.1038/s41467-020-16505-0.
Nat Commun. 2020.
PMID: 32433465
Free PMC article.
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Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates.
Walters JN, Schouest B, Patel A, Reuschel EL, Schultheis K, Parzych E, Maricic I, Gary EN, Purwar M, Andrade VM, Doan A, Elwood D, Eblimit Z, Nguyen B, Frase D, Zaidi FI, Kulkarni A, Generotti A, Joseph Kim J, Humeau LM, Ramos SJ, Smith TRF, Weiner DB, Broderick KE.
Walters JN, et al. Among authors: generotti a.
Vaccine. 2022 May 9;40(21):2960-2969. doi: 10.1016/j.vaccine.2022.03.060. Epub 2022 Apr 4.
Vaccine. 2022.
PMID: 35428500
Free PMC article.
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Intradermal DNA vaccine delivery using vacuum-controlled, needle-free electroporation.
Generotti A, Contreras R, Zounes B, Schade E, Kemme A, Rane Y, Liu X, Elwood D, Schultheis K, Marston J, McCoy J, Broderick K, Fisher P.
Generotti A, et al.
Mol Ther Nucleic Acids. 2023 Oct 31;34:102070. doi: 10.1016/j.omtn.2023.102070. eCollection 2023 Dec 12.
Mol Ther Nucleic Acids. 2023.
PMID: 38034030
Free PMC article.
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In vivo delivery of engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis in non-human primates.
Patel A, Rosenke K, Parzych EM, Feldmann F, Bharti S, Griffin AJ, Schouest B, Lewis M, Choi J, Chokkalingam N, Machado V, Smith BJ, Frase D, Ali AR, Lovaglio J, Nguyen B, Hanley PW, Walker SN, Gary EN, Kulkarni A, Generotti A, Francica JR, Rosenthal K, Kulp DW, Esser MT, Smith TRF, Shaia C, Weiner DB, Feldmann H.
Patel A, et al. Among authors: generotti a.
Emerg Microbes Infect. 2024 Dec;13(1):2294860. doi: 10.1080/22221751.2023.2294860. Epub 2024 Feb 28.
Emerg Microbes Infect. 2024.
PMID: 38165394
Free PMC article.
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