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Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans.
Lim HK, Chen J, Lam W, Gong Y, Leclercq L, Silva J, Salter R, Berwaerts J, Gelotte CK, Vakil AM, Eichenbaum GE, Kuffner EK, Flores CM. Lim HK, et al. Among authors: gelotte ck. Regul Toxicol Pharmacol. 2023 Mar 16:105379. doi: 10.1016/j.yrtph.2023.105379. Online ahead of print. Regul Toxicol Pharmacol. 2023. PMID: 36931586 Free article.
A critical review of the acetaminophen preclinical carcinogenicity and tumor promotion data and their implications for its carcinogenic hazard potential.
Murray FJ, Monnot AD, Jacobson-Kram D, Cohen SM, Hardisty JF, Bandara SB, Kovochich M, Deore M, Pitchaiyan SK, Gelotte CK, Lai JCK, Atillasoy E, Hermanowski-Vosatka A, Kuffner E, Unice KM, Yang K, Gebremichael Y, Howell BA, Eichenbaum G. Murray FJ, et al. Among authors: gelotte ck. Regul Toxicol Pharmacol. 2020 Dec;118:104801. doi: 10.1016/j.yrtph.2020.104801. Epub 2020 Oct 9. Regul Toxicol Pharmacol. 2020. PMID: 33039518 Free article. Review.
Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen.
Eichenbaum G, Yang K, Gebremichael Y, Howell BA, Murray FJ, Jacobson-Kram D, Jaeschke H, Kuffner E, Gelotte CK, Lai JCK, Wikoff D, Atillasoy E. Eichenbaum G, et al. Among authors: gelotte ck. Regul Toxicol Pharmacol. 2020 Dec;118:104788. doi: 10.1016/j.yrtph.2020.104788. Epub 2020 Oct 22. Regul Toxicol Pharmacol. 2020. PMID: 33153971 Free article.
JNJ-10450232 (NTM-006), A novel non-opioid with structural similarities to acetaminophen, produces relatively long-lasting analgesia after a single dose in patients undergoing 3rd molar extraction.
Gelotte CK, Vakil AM, Zimmerman BA, Zannikos P, Mishra R, Eichenbaum G, Kuffner EK, Flores CM. Gelotte CK, et al. Regul Toxicol Pharmacol. 2023 Aug 23:105480. doi: 10.1016/j.yrtph.2023.105480. Online ahead of print. Regul Toxicol Pharmacol. 2023. PMID: 37625518 Free article.
20 results