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Inhibitors of specific ceramide synthases.
Schiffmann S, Hartmann D, Fuchs S, Birod K, Ferreiròs N, Schreiber Y, Zivkovic A, Geisslinger G, Grösch S, Stark H. Schiffmann S, et al. Among authors: geisslinger g. Biochimie. 2012 Feb;94(2):558-65. doi: 10.1016/j.biochi.2011.09.007. Epub 2011 Sep 17. Biochimie. 2012. PMID: 21945810
Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation.
Brenneis C, Sisignano M, Coste O, Altenrath K, Fischer MJ, Angioni C, Fleming I, Brandes RP, Reeh PW, Woolf CJ, Geisslinger G, Scholich K. Brenneis C, et al. Among authors: geisslinger g. Mol Pain. 2011 Oct 4;7:78. doi: 10.1186/1744-8069-7-78. Mol Pain. 2011. PMID: 21970373 Free PMC article.
5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.
Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C. Sisignano M, et al. Among authors: geisslinger g. J Neurosci. 2012 May 2;32(18):6364-72. doi: 10.1523/JNEUROSCI.5793-11.2012. J Neurosci. 2012. PMID: 22553041 Free PMC article.
Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation.
Linke B, Schreiber Y, Zhang DD, Pierre S, Coste O, Henke M, Suo J, Fuchs J, Angioni C, Ferreiros-Bouzas N, Geisslinger G, Scholich K. Linke B, et al. Among authors: geisslinger g. Prostaglandins Other Lipid Mediat. 2012 Oct;99(1-2):15-23. doi: 10.1016/j.prostaglandins.2012.06.002. Epub 2012 Jun 23. Prostaglandins Other Lipid Mediat. 2012. PMID: 22732087
598 results