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Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells.
De Simone M, Arrigoni A, Rossetti G, Gruarin P, Ranzani V, Politano C, Bonnal RJP, Provasi E, Sarnicola ML, Panzeri I, Moro M, Crosti M, Mazzara S, Vaira V, Bosari S, Palleschi A, Santambrogio L, Bovo G, Zucchini N, Totis M, Gianotti L, Cesana G, Perego RA, Maroni N, Pisani Ceretti A, Opocher E, De Francesco R, Geginat J, Stunnenberg HG, Abrignani S, Pagani M. De Simone M, et al. Among authors: geginat j. Immunity. 2016 Nov 15;45(5):1135-1147. doi: 10.1016/j.immuni.2016.10.021. Immunity. 2016. PMID: 27851914 Free PMC article.
CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function.
Rivino L, Gruarin P, Häringer B, Steinfelder S, Lozza L, Steckel B, Weick A, Sugliano E, Jarrossay D, Kühl AA, Loddenkemper C, Abrignani S, Sallusto F, Lanzavecchia A, Geginat J. Rivino L, et al. Among authors: geginat j. J Exp Med. 2010 Mar 15;207(3):565-77. doi: 10.1084/jem.20091021. Epub 2010 Mar 1. J Exp Med. 2010. PMID: 20194631 Free PMC article.
Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.
Rossi RL, Rossetti G, Wenandy L, Curti S, Ripamonti A, Bonnal RJ, Birolo RS, Moro M, Crosti MC, Gruarin P, Maglie S, Marabita F, Mascheroni D, Parente V, Comelli M, Trabucchi E, De Francesco R, Geginat J, Abrignani S, Pagani M. Rossi RL, et al. Among authors: geginat j. Nat Immunol. 2011 Jun 26;12(8):796-803. doi: 10.1038/ni.2057. Nat Immunol. 2011. PMID: 21706005
Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis.
Zingaretti C, Arigò M, Cardaci A, Moro M, Crosti M, Sinisi A, Sugliano E, Cheroni C, Marabita F, Nogarotto R, Bonnal RJ, Marcatili P, Marconi M, Zignego A, Muratori P, Invernizzi P, Colombatto P, Brunetto M, Bonino F, De Francesco R, Geginat J, Pagani M, Muratori L, Abrignani S, Bombaci M. Zingaretti C, et al. Among authors: geginat j. Mol Cell Proteomics. 2012 Dec;11(12):1885-97. doi: 10.1074/mcp.M112.018713. Epub 2012 Sep 20. Mol Cell Proteomics. 2012. PMID: 22997428 Free PMC article.
Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.
Nizzoli G, Krietsch J, Weick A, Steinfelder S, Facciotti F, Gruarin P, Bianco A, Steckel B, Moro M, Crosti M, Romagnani C, Stölzel K, Torretta S, Pignataro L, Scheibenbogen C, Neddermann P, De Francesco R, Abrignani S, Geginat J. Nizzoli G, et al. Among authors: geginat j. Blood. 2013 Aug 8;122(6):932-42. doi: 10.1182/blood-2013-04-495424. Epub 2013 Jun 21. Blood. 2013. PMID: 23794066 Free article.
The CD4-centered universe of human T cell subsets.
Geginat J, Paroni M, Facciotti F, Gruarin P, Kastirr I, Caprioli F, Pagani M, Abrignani S. Geginat J, et al. Semin Immunol. 2013 Nov 15;25(4):252-62. doi: 10.1016/j.smim.2013.10.012. Epub 2013 Nov 1. Semin Immunol. 2013. PMID: 24183700 Review.
Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation.
de Candia P, Torri A, Gorletta T, Fedeli M, Bulgheroni E, Cheroni C, Marabita F, Crosti M, Moro M, Pariani E, Romanò L, Esposito S, Mosca F, Rossetti G, Rossi RL, Geginat J, Casorati G, Dellabona P, Pagani M, Abrignani S. de Candia P, et al. Among authors: geginat j. PLoS One. 2013 Sep 26;8(9):e75348. doi: 10.1371/journal.pone.0075348. eCollection 2013. PLoS One. 2013. PMID: 24205408 Free PMC article.
IL-21 is a central memory T cell-associated cytokine that inhibits the generation of pathogenic Th1/17 effector cells.
Kastirr I, Maglie S, Paroni M, Alfen JS, Nizzoli G, Sugliano E, Crosti MC, Moro M, Steckel B, Steinfelder S, Stölzel K, Romagnani C, Botti F, Caprioli F, Pagani M, Abrignani S, Geginat J. Kastirr I, et al. Among authors: geginat j. J Immunol. 2014 Oct 1;193(7):3322-31. doi: 10.4049/jimmunol.1400775. Epub 2014 Aug 29. J Immunol. 2014. PMID: 25172491 Clinical Trial.
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