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A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner.
Nat Biotechnol. 2009 Dec;27(12):1186-90. doi: 10.1038/nbt.1588.
Nat Biotechnol. 2009.
PMID: 19915550
Gcg-XTEN: an improved glucagon capable of preventing hypoglycemia without increasing baseline blood glucose.
Geething NC, To W, Spink BJ, Scholle MD, Wang CW, Yin Y, Yao Y, Schellenberger V, Cleland JL, Stemmer WP, Silverman J.
Geething NC, et al.
PLoS One. 2010 Apr 14;5(4):e10175. doi: 10.1371/journal.pone.0010175.
PLoS One. 2010.
PMID: 20418955
Free PMC article.
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A novel long-acting human growth hormone fusion protein (VRS-317): enhanced in vivo potency and half-life.
Cleland JL, Geething NC, Moore JA, Rogers BC, Spink BJ, Wang CW, Alters SE, Stemmer WP, Schellenberger V.
Cleland JL, et al. Among authors: geething nc.
J Pharm Sci. 2012 Aug;101(8):2744-54. doi: 10.1002/jps.23229. Epub 2012 Jun 7.
J Pharm Sci. 2012.
PMID: 22678811
Free PMC article.
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Identification of a minimal myosin Va binding site within an intrinsically unstructured domain of melanophilin.
Geething NC, Spudich JA.
Geething NC, et al.
J Biol Chem. 2007 Jul 20;282(29):21518-28. doi: 10.1074/jbc.M701932200. Epub 2007 May 19.
J Biol Chem. 2007.
PMID: 17513864
Free article.
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Drs2p-dependent formation of exocytic clathrin-coated vesicles in vivo.
Gall WE, Geething NC, Hua Z, Ingram MF, Liu K, Chen SI, Graham TR.
Gall WE, et al. Among authors: geething nc.
Curr Biol. 2002 Sep 17;12(18):1623-7. doi: 10.1016/s0960-9822(02)01148-x.
Curr Biol. 2002.
PMID: 12372257
Free article.
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