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A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation.
Schanin J, Gebremeskel S, Korver W, Falahati R, Butuci M, Haw TJ, Nair PM, Liu G, Hansbro NG, Hansbro PM, Evensen E, Brock EC, Xu A, Wong A, Leung J, Bebbington C, Tomasevic N, Youngblood BA. Schanin J, et al. Among authors: gebremeskel s. Mucosal Immunol. 2021 Mar;14(2):366-376. doi: 10.1038/s41385-020-00336-9. Epub 2020 Aug 19. Mucosal Immunol. 2021. PMID: 32814824 Free PMC article.
The Inhibitory Receptor Siglec-8 Interacts With FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation.
Korver W, Wong A, Gebremeskel S, Negri GL, Schanin J, Chang K, Leung J, Benet Z, Luu T, Brock EC, Luehrsen K, Xu A, Youngblood BA. Korver W, et al. Among authors: gebremeskel s. Front Immunol. 2022 Jan 28;13:833728. doi: 10.3389/fimmu.2022.833728. eCollection 2022. Front Immunol. 2022. PMID: 35154156 Free PMC article.
34 results