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Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus.
Hasni SA, Gupta S, Davis M, Poncio E, Temesgen-Oyelakin Y, Carlucci PM, Wang X, Naqi M, Playford MP, Goel RR, Li X, Biehl AJ, Ochoa-Navas I, Manna Z, Shi Y, Thomas D, Chen J, Biancotto A, Apps R, Cheung F, Kotliarov Y, Babyak AL, Zhou H, Shi R, Stagliano K, Tsai WL, Vian L, Gazaniga N, Giudice V, Lu S, Brooks SR, MacKay M, Gregersen P, Mehta NN, Remaley AT, Diamond B, O'Shea JJ, Gadina M, Kaplan MJ. Hasni SA, et al. Among authors: gazaniga n. Nat Commun. 2021 Jun 7;12(1):3391. doi: 10.1038/s41467-021-23361-z. Nat Commun. 2021. PMID: 34099646 Free PMC article. Clinical Trial.
JAK Inhibition Differentially Affects NK Cell and ILC1 Homeostasis.
Vian L, Le MT, Gazaniga N, Kieltyka J, Liu C, Pietropaolo G, Dell'Orso S, Brooks SR, Furumoto Y, Thomas CJ, O'Shea JJ, Sciumè G, Gadina M. Vian L, et al. Among authors: gazaniga n. Front Immunol. 2019 Dec 19;10:2972. doi: 10.3389/fimmu.2019.02972. eCollection 2019. Front Immunol. 2019. PMID: 31921209 Free PMC article.
Synthesis of portimines reveals the basis of their anti-cancer activity.
Tang J, Li W, Chiu TY, Martínez-Peña F, Luo Z, Chong CT, Wei Q, Gazaniga N, West TJ, See YY, Lairson LL, Parker CG, Baran PS. Tang J, et al. Among authors: gazaniga n. Nature. 2023 Oct;622(7983):507-513. doi: 10.1038/s41586-023-06535-1. Epub 2023 Sep 20. Nature. 2023. PMID: 37730997
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux.
Spangenberg SH, Palermo A, Gazaniga NR, Martínez-Peña F, Guijas C, Chin EN, Rinschen MM, Sander PN, Webb B, Pereira LE, Jia Y, Meitz L, Siuzdak G, Lairson LL. Spangenberg SH, et al. Among authors: gazaniga nr. Cell Chem Biol. 2023 Sep 21;30(9):1115-1134.e10. doi: 10.1016/j.chembiol.2023.06.016. Epub 2023 Jul 18. Cell Chem Biol. 2023. PMID: 37467751
Suppression of tumor-derived Semaphorin 7A and genetic ablation of host-derived Semaphorin 7A impairs tumor progression in a murine model of advanced breast carcinoma.
Garcia-Areas R, Libreros S, Simoes M, Castro-Silva C, Gazaniga N, Amat S, Jaczewska J, Keating P, Schilling K, Brito M, Wojcikiewicz EP, Iragavarpu-Charyulu V. Garcia-Areas R, et al. Among authors: gazaniga n. Int J Oncol. 2017 Nov;51(5):1395-1404. doi: 10.3892/ijo.2017.4144. Epub 2017 Oct 3. Int J Oncol. 2017. PMID: 29048670 Free PMC article.
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