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The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes.
Olombrada M, Peña C, Rodríguez-Galán O, Klingauf-Nerurkar P, Portugal-Calisto D, Oborská-Oplová M, Altvater M, Gavilanes JG, Martínez-Del-Pozo Á, de la Cruz J, García-Ortega L, Panse VG. Olombrada M, et al. Among authors: gavilanes jg. Nucleic Acids Res. 2020 Jun 19;48(11):6210-6222. doi: 10.1093/nar/gkaa315. Nucleic Acids Res. 2020. PMID: 32365182 Free PMC article.
The ribonucleolytic activity of the ribotoxin α-sarcin is not essential for in vitro protein biosynthesis inhibition.
Alvarez-García E, Diago-Navarro E, Herrero-Galán E, García-Ortega L, López-Villarejo J, Olmo N, Díaz-Orejas R, Gavilanes JG, Martínez-del-Pozo A. Alvarez-García E, et al. Among authors: gavilanes jg. Biochim Biophys Acta. 2011 Oct;1814(10):1377-82. doi: 10.1016/j.bbapap.2011.06.017. Epub 2011 Jul 13. Biochim Biophys Acta. 2011. PMID: 21767671 Free article.
Modeling the highly specific ribotoxin recognition of ribosomes.
García-Mayoral F, García-Ortega L, Alvarez-García E, Bruix M, Gavilanes JG, del Pozo AM. García-Mayoral F, et al. Among authors: gavilanes jg. FEBS Lett. 2005 Dec 19;579(30):6859-64. doi: 10.1016/j.febslet.2005.11.027. Epub 2005 Dec 1. FEBS Lett. 2005. PMID: 16337202 Free article.
186 results