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First evidence that oligopyridines, α-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies.
Gloaguen C, Voisin-Chiret AS, Sopkova-de Oliveira Santos J, Fogha J, Gautier F, De Giorgi M, Burzicki G, Perato S, Pétigny-Lechartier C, Simonin-Le Jeune K, Brotin E, Goux D, N'Diaye M, Lambert B, Louis MH, Ligat L, Lopez F, Juin P, Bureau R, Rault S, Poulain L. Gloaguen C, et al. Among authors: gautier f. J Med Chem. 2015 Feb 26;58(4):1644-68. doi: 10.1021/jm500672y. Epub 2015 Feb 4. J Med Chem. 2015. PMID: 25585174
Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode.
Hedir S, De Giorgi M, Fogha J, De Pascale M, Weiswald LB, Brotin E, Marekha B, Denoyelle C, Denis C, Suzanne P, Gautier F, Juin P, Ligat L, Lopez F, Carlier L, Legay R, Bureau R, Rault S, Poulain L, Oliveira Santos JS, Voisin-Chiret AS. Hedir S, et al. Among authors: gautier f. Eur J Med Chem. 2018 Nov 5;159:357-380. doi: 10.1016/j.ejmech.2018.10.003. Epub 2018 Oct 4. Eur J Med Chem. 2018. PMID: 30308410
Decoding and unlocking the BCL-2 dependency of cancer cells.
Juin P, Geneste O, Gautier F, Depil S, Campone M. Juin P, et al. Among authors: gautier f. Nat Rev Cancer. 2013 Jul;13(7):455-65. doi: 10.1038/nrc3538. Epub 2013 Jun 20. Nat Rev Cancer. 2013. PMID: 23783119 Review.
Synthesis and biological studies of new piperidino-1,2,3-triazole hybrids with 3-aryl isoxazole side chains.
Murthy AVR, Narendar V, Sampath Kumar N, Aparna P, Bhavani AKD, Solhi H, Le Guevel R, Roul J, Gautier F, Juin P, Reddy CR, Mosset P, Levoin N, Grée R. Murthy AVR, et al. Among authors: gautier f. Bioorg Med Chem Lett. 2021 Nov 15;52:128390. doi: 10.1016/j.bmcl.2021.128390. Epub 2021 Sep 30. Bioorg Med Chem Lett. 2021. PMID: 34601029 Free article.
105 results