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Exploiting the S4-S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis.
Guarino C, Gruba N, Grzywa R, Dyguda-Kazimierowicz E, Hamon Y, Łȩgowska M, Skoreński M, Dallet-Choisy S, Marchand-Adam S, Kellenberger C, Jenne DE, Sieńczyk M, Lesner A, Gauthier F, Korkmaz B. Guarino C, et al. Among authors: gauthier f. J Med Chem. 2018 Mar 8;61(5):1858-1870. doi: 10.1021/acs.jmedchem.7b01416. Epub 2018 Feb 26. J Med Chem. 2018. PMID: 29442501
Selective inhibitors of human neutrophil proteinase 3.
Korkmaz B, Kellenberger C, Viaud-Massuard MC, Gauthier F. Korkmaz B, et al. Among authors: gauthier f. Curr Pharm Des. 2013;19(6):966-76. doi: 10.2174/1381612811319060002. Curr Pharm Des. 2013. PMID: 23016687 Review.
New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases.
Guarino C, Legowska M, Epinette C, Kellenberger C, Dallet-Choisy S, Sieńczyk M, Gabant G, Cadene M, Zoidakis J, Vlahou A, Wysocka M, Marchand-Adam S, Jenne DE, Lesner A, Gauthier F, Korkmaz B. Guarino C, et al. Among authors: gauthier f. J Biol Chem. 2014 Nov 14;289(46):31777-31791. doi: 10.1074/jbc.M114.591339. Epub 2014 Oct 6. J Biol Chem. 2014. PMID: 25288799 Free PMC article.
Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.
Hamon Y, Legowska M, Hervé V, Dallet-Choisy S, Marchand-Adam S, Vanderlynden L, Demonte M, Williams R, Scott CJ, Si-Tahar M, Heuzé-Vourc'h N, Lalmanach G, Jenne DE, Lesner A, Gauthier F, Korkmaz B. Hamon Y, et al. Among authors: gauthier f. J Biol Chem. 2016 Apr 15;291(16):8486-99. doi: 10.1074/jbc.M115.707109. Epub 2016 Feb 16. J Biol Chem. 2016. PMID: 26884336 Free PMC article.
Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin.
N'Guessan K, Grzywa R, Seren S, Gabant G, Juliano MA, Moniatte M, van Dorsselaer A, Bieth JG, Kellenberger C, Gauthier F, Wysocka M, Lesner A, Sienczyk M, Cadene M, Korkmaz B. N'Guessan K, et al. Among authors: gauthier f. FEBS J. 2020 Sep;287(18):4068-4081. doi: 10.1111/febs.15229. Epub 2020 Feb 24. FEBS J. 2020. PMID: 31995266 Free article.
350 results