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Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.
Ghiboub M, Koster J, Craggs PD, Li Yim AYF, Shillings A, Hutchinson S, Bingham RP, Gatfield K, Hageman IL, Yao G, O'Keefe HP, Coffin A, Patel A, Sloan LA, Mitchell DJ, Hayhow TG, Lunven L, Watson RJ, Blunt CE, Harrison LA, Bruton G, Kumar U, Hamer N, Spaull JR, Zwijnenburg DA, Welting O, Hakvoort TBM, Te Velde AA, van Limbergen J, Henneman P, Prinjha RK, de Winther MPJ, Harker NR, Tough DF, de Jonge WJ. Ghiboub M, et al. Among authors: gatfield k. BMC Biol. 2022 Aug 19;20(1):182. doi: 10.1186/s12915-022-01380-6. BMC Biol. 2022. PMID: 35986286 Free PMC article.
Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions.
Phillipou AN, Lay CS, Carver CE, Messenger C, Evans JP, Lewis AJ, Gordon LJ, Mahmood M, Greenhough LA, Sammon D, Cheng AT, Chakraborty S, Jones EJ, Lucas SCC, Gatfield KM, Brierley DJ, Craggs PD. Phillipou AN, et al. Among authors: gatfield km. SLAS Discov. 2020 Feb;25(2):163-175. doi: 10.1177/2472555219896278. Epub 2019 Dec 25. SLAS Discov. 2020. PMID: 31875412 Free article.
Development of an intracellular quantitative assay to measure compound binding kinetics.
Lay CS, Thomas DA, Evans JP, Campbell M, McCombe K, Phillipou AN, Gordon LJ, Jones EJ, Riching K, Mahmood M, Messenger C, Carver CE, Gatfield KM, Craggs PD. Lay CS, et al. Among authors: gatfield km. Cell Chem Biol. 2022 Feb 17;29(2):287-299.e8. doi: 10.1016/j.chembiol.2021.07.018. Epub 2021 Sep 13. Cell Chem Biol. 2022. PMID: 34520747 Free article.
Development of an intracellular quantitative assay to measure compound binding kinetics.
Lay CS, Thomas DA, Evans JP, Campbell M, McCombe K, Phillipou AN, Gordon LJ, Jones EJ, Riching K, Mahmood M, Messenger C, Carver CE, Gatfield KM, Craggs PD. Lay CS, et al. Among authors: gatfield km. Cell Chem Biol. 2023 Dec 21;30(12):1692. doi: 10.1016/j.chembiol.2023.12.001. Cell Chem Biol. 2023. PMID: 38134882 No abstract available.
13 results