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Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease.
Gate D, Saligrama N, Leventhal O, Yang AC, Unger MS, Middeldorp J, Chen K, Lehallier B, Channappa D, De Los Santos MB, McBride A, Pluvinage J, Elahi F, Tam GK, Kim Y, Greicius M, Wagner AD, Aigner L, Galasko DR, Davis MM, Wyss-Coray T. Gate D, et al. Nature. 2020 Jan;577(7790):399-404. doi: 10.1038/s41586-019-1895-7. Epub 2020 Jan 8. Nature. 2020. PMID: 31915375 Free PMC article.
CD4+ T cells contribute to neurodegeneration in Lewy body dementia.
Gate D, Tapp E, Leventhal O, Shahid M, Nonninger TJ, Yang AC, Strempfl K, Unger MS, Fehlmann T, Oh H, Channappa D, Henderson VW, Keller A, Aigner L, Galasko DR, Davis MM, Poston KL, Wyss-Coray T. Gate D, et al. Science. 2021 Nov 12;374(6569):868-874. doi: 10.1126/science.abf7266. Epub 2021 Oct 14. Science. 2021. PMID: 34648304 Free PMC article.
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.
Pluvinage JV, Haney MS, Smith BAH, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik MC, Wyss-Coray T. Pluvinage JV, et al. Among authors: gate d. Nature. 2019 Apr;568(7751):187-192. doi: 10.1038/s41586-019-1088-4. Epub 2019 Apr 3. Nature. 2019. PMID: 30944478 Free PMC article.
Undulating changes in human plasma proteome profiles across the lifespan.
Lehallier B, Gate D, Schaum N, Nanasi T, Lee SE, Yousef H, Moran Losada P, Berdnik D, Keller A, Verghese J, Sathyan S, Franceschi C, Milman S, Barzilai N, Wyss-Coray T. Lehallier B, et al. Among authors: gate d. Nat Med. 2019 Dec;25(12):1843-1850. doi: 10.1038/s41591-019-0673-2. Epub 2019 Dec 5. Nat Med. 2019. PMID: 31806903 Free PMC article.
Physiological blood-brain transport is impaired with age by a shift in transcytosis.
Yang AC, Stevens MY, Chen MB, Lee DP, Stähli D, Gate D, Contrepois K, Chen W, Iram T, Zhang L, Vest RT, Chaney A, Lehallier B, Olsson N, du Bois H, Hsieh R, Cropper HC, Berdnik D, Li L, Wang EY, Traber GM, Bertozzi CR, Luo J, Snyder MP, Elias JE, Quake SR, James ML, Wyss-Coray T. Yang AC, et al. Among authors: gate d. Nature. 2020 Jul;583(7816):425-430. doi: 10.1038/s41586-020-2453-z. Epub 2020 Jul 1. Nature. 2020. PMID: 32612231 Free PMC article.
Dysregulation of brain and choroid plexus cell types in severe COVID-19.
Yang AC, Kern F, Losada PM, Agam MR, Maat CA, Schmartz GP, Fehlmann T, Stein JA, Schaum N, Lee DP, Calcuttawala K, Vest RT, Berdnik D, Lu N, Hahn O, Gate D, McNerney MW, Channappa D, Cobos I, Ludwig N, Schulz-Schaeffer WJ, Keller A, Wyss-Coray T. Yang AC, et al. Among authors: gate d. Nature. 2021 Jul;595(7868):565-571. doi: 10.1038/s41586-021-03710-0. Epub 2021 Jun 21. Nature. 2021. PMID: 34153974 Free PMC article.
A human brain vascular atlas reveals diverse mediators of Alzheimer's risk.
Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, Losada PM, Chen MB, Schaum N, Khoury N, Toland A, Calcuttawala K, Shin H, Pálovics R, Shin A, Wang EY, Luo J, Gate D, Schulz-Schaeffer WJ, Chu P, Siegenthaler JA, McNerney MW, Keller A, Wyss-Coray T. Yang AC, et al. Among authors: gate d. Nature. 2022 Mar;603(7903):885-892. doi: 10.1038/s41586-021-04369-3. Epub 2022 Feb 14. Nature. 2022. PMID: 35165441 Free PMC article.
Transcriptomic Profiling Identifies CD8+ T Cells in the Brain of Aged and Alzheimer's Disease Transgenic Mice as Tissue-Resident Memory T Cells.
Altendorfer B, Unger MS, Poupardin R, Hoog A, Asslaber D, Gratz IK, Mrowetz H, Benedetti A, de Sousa DMB, Greil R, Egle A, Gate D, Wyss-Coray T, Aigner L. Altendorfer B, et al. Among authors: gate d. J Immunol. 2022 Oct 1;209(7):1272-1285. doi: 10.4049/jimmunol.2100737. Epub 2022 Aug 31. J Immunol. 2022. PMID: 36165202 Free PMC article.
Publisher Correction: Dysregulation of brain and choroid plexus cell types in severe COVID-19.
Yang AC, Kern F, Losada PM, Agam MR, Maat CA, Schmartz GP, Fehlmann T, Stein JA, Schaum N, Lee DP, Calcuttawala K, Vest RT, Berdnik D, Lu N, Hahn O, Gate D, McNerney MW, Channappa D, Cobos I, Ludwig N, Schulz-Schaeffer WJ, Keller A, Wyss-Coray T. Yang AC, et al. Among authors: gate d. Nature. 2021 Oct;598(7882):E4. doi: 10.1038/s41586-021-04080-3. Nature. 2021. PMID: 34625744 Free PMC article. No abstract available.
34 results