Gaster LM - Search Results

1

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.

Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. Inman GJ, et al. Among authors: gaster lm. Mol Pharmacol. 2002 Jul;62(1):65-74. doi: 10.1124/mol.62.1.65. Mol Pharmacol. 2002. PMID: 12065756

2

Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.

Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, Martin W, Fornwald J, Lehr R, Harling J, Gaster L, Callahan JF, Olson BA. Laping NJ, et al. Mol Pharmacol. 2002 Jul;62(1):58-64. doi: 10.1124/mol.62.1.58. Mol Pharmacol. 2002. PMID: 12065755

3

Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).

Callahan JF, Burgess JL, Fornwald JA, Gaster LM, Harling JD, Harrington FP, Heer J, Kwon C, Lehr R, Mathur A, Olson BA, Weinstock J, Laping NJ. Callahan JF, et al. Among authors: gaster lm. J Med Chem. 2002 Feb 28;45(5):999-1001. doi: 10.1021/jm010493y. J Med Chem. 2002. PMID: 11855979

4

Blockade of human atrial 5-HT4 receptors by SB 207710, a selective and high affinity 5-HT4 receptor antagonist.

Kaumann AJ, Gaster LM, King FD, Brown AM. Kaumann AJ, et al. Among authors: gaster lm. Naunyn Schmiedebergs Arch Pharmacol. 1994 May;349(5):546-8. doi: 10.1007/BF00169146. Naunyn Schmiedebergs Arch Pharmacol. 1994. PMID: 7915008

5

SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor.

Middlemiss DN, Göthert M, Schlicker E, Scott CM, Selkirk JV, Watson J, Gaster LM, Wyman P, Riley G, Price GW. Middlemiss DN, et al. Among authors: gaster lm. Eur J Pharmacol. 1999 Jun 30;375(1-3):359-65. doi: 10.1016/s0014-2999(99)00262-9. Eur J Pharmacol. 1999. PMID: 10443589

6

Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig.

Hagan JJ, Slade PD, Gaster L, Jeffrey P, Hatcher JP, Middlemiss DN. Hagan JJ, et al. Eur J Pharmacol. 1997 Jul 23;331(2-3):169-74. doi: 10.1016/s0014-2999(97)01055-8. Eur J Pharmacol. 1997. PMID: 9274976

7

SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors.

Price GW, Burton MJ, Collin LJ, Duckworth M, Gaster L, Göthert M, Jones BJ, Roberts C, Watson JM, Middlemiss DN. Price GW, et al. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. doi: 10.1007/pl00005056. Naunyn Schmiedebergs Arch Pharmacol. 1997. PMID: 9303567

8

8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: potent, selective, orally bioavailable 5-HT1 receptor ligands.

Heightman TD, Gaster LM, Pardoe SL, Pilleux JP, Hadley MS, Middlemiss DN, Price GW, Roberts C, Scott CM, Watson JM, Gordon LJ, Holland VA, Powles J, Riley GJ, Stean TO, Trail BK, Upton N, Austin NE, Ayrton AD, Coleman T, Cutler L. Heightman TD, et al. Among authors: gaster lm. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4370-4. doi: 10.1016/j.bmcl.2005.06.042. Bioorg Med Chem Lett. 2005. PMID: 16039851

9

N-[(1-butyl-4-piperidinyl)methyl]-3,4dihydro-2H-[1,3]oxazino[3,2- a]indole10-carboxamide hydrochloride: the first potent and selective 5-HT4 receptor antagonist amide with oral activity.

Gaster LM, Joiner GF, King FD, Wyman PA, Sutton JM, Bingham S, Ellis ES, Sanger GJ, Wardle KA. Gaster LM, et al. J Med Chem. 1995 Nov 24;38(24):4760-3. doi: 10.1021/jm00024a002. J Med Chem. 1995. PMID: 7490724 No abstract available.

10

Synthesis of novel modified dipeptide inhibitors of human collagenase: beta-mercapto carboxylic acid derivatives.

Beszant B, Bird J, Gaster LM, Harper GP, Hughes I, Karran EH, Markwell RE, Miles-Williams AJ, Smith SA. Beszant B, et al. Among authors: gaster lm. J Med Chem. 1993 Dec 10;36(25):4030-9. doi: 10.1021/jm00077a006. J Med Chem. 1993. PMID: 8258825

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