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Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition.
Ferrucci V, de Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, Navas L, Diana D, Pedone E, Gargiulo S, Gramanzini M, Brunetti A, Danielson L, Carotenuto M, Liguori L, Verrico A, Quaglietta L, Errico ME, Del Monaco V, D'Argenio V, Tirone F, Mastronuzzi A, Donofrio V, Giangaspero F, Picard D, Remke M, Garzia L, Daniels C, Delattre O, Swartling FJ, Weiss WA, Salvatore F, Fattorusso R, Chesler L, Taylor MD, Cinalli G, Zollo M. Ferrucci V, et al. Among authors: garzia l. Brain. 2018 May 1;141(5):1300-1319. doi: 10.1093/brain/awy039. Brain. 2018. PMID: 29490009
Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis.
D'Angelo A, Garzia L, André A, Carotenuto P, Aglio V, Guardiola O, Arrigoni G, Cossu A, Palmieri G, Aravind L, Zollo M. D'Angelo A, et al. Among authors: garzia l. Cancer Cell. 2004 Feb;5(2):137-49. doi: 10.1016/s1535-6108(04)00021-2. Cancer Cell. 2004. PMID: 14998490 Free article.
MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma.
Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Vecchio LD, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M. Garzia L, et al. PLoS One. 2009;4(3):e4998. doi: 10.1371/journal.pone.0004998. Epub 2009 Mar 24. PLoS One. 2009. PMID: 19308264 Free PMC article.
PCDH10 is a candidate tumour suppressor gene in medulloblastoma.
Bertrand KC, Mack SC, Northcott PA, Garzia L, Dubuc A, Pfister SM, Rutka JT, Weiss WA, Taylor MD. Bertrand KC, et al. Among authors: garzia l. Childs Nerv Syst. 2011 Aug;27(8):1243-9. doi: 10.1007/s00381-011-1486-x. Epub 2011 May 20. Childs Nerv Syst. 2011. PMID: 21597995
Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma.
Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R, Benner A, Hielscher T, Milde T, Remke M, Jones DT, Northcott PA, Garzia L, Bertrand KC, Wittmann A, Yao Y, Roberts SS, Massimi L, Van Meter T, Weiss WA, Gupta N, Grajkowska W, Lach B, Cho YJ, von Deimling A, Kulozik AE, Witt O, Bader GD, Hawkins CE, Tabori U, Guha A, Rutka JT, Lichter P, Korshunov A, Taylor MD, Pfister SM. Witt H, et al. Among authors: garzia l. Cancer Cell. 2011 Aug 16;20(2):143-57. doi: 10.1016/j.ccr.2011.07.007. Cancer Cell. 2011. PMID: 21840481 Free PMC article.
Clonal selection drives genetic divergence of metastatic medulloblastoma.
Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, Witt H, Croul S, Bouffet E, Fults DW, Eberhart CG, Garzia L, Van Meter T, Zagzag D, Jabado N, Schwartzentruber J, Majewski J, Scheetz TE, Pfister SM, Korshunov A, Li XN, Scherer SW, Cho YJ, Akagi K, MacDonald TJ, Koster J, McCabe MG, Sarver AL, Collins VP, Weiss WA, Largaespada DA, Collier LS, Taylor MD. Wu X, et al. Among authors: garzia l. Nature. 2012 Feb 15;482(7386):529-33. doi: 10.1038/nature10825. Nature. 2012. PMID: 22343890 Free PMC article.
The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma.
Andolfo I, Liguori L, De Antonellis P, Cusanelli E, Marinaro F, Pistollato F, Garzia L, De Vita G, Petrosino G, Accordi B, Migliorati R, Basso G, Iolascon A, Cinalli G, Zollo M. Andolfo I, et al. Among authors: garzia l. Neuro Oncol. 2012 May;14(5):596-612. doi: 10.1093/neuonc/nos002. Epub 2012 Mar 12. Neuro Oncol. 2012. PMID: 22411914 Free PMC article.
66 results