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The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.
Garvey EP, Johns BA, Gartland MJ, Foster SA, Miller WH, Ferris RG, Hazen RJ, Underwood MR, Boros EE, Thompson JB, Weatherhead JG, Koble CS, Allen SH, Schaller LT, Sherrill RG, Yoshinaga T, Kobayashi M, Wakasa-Morimoto C, Miki S, Nakahara K, Noshi T, Sato A, Fujiwara T. Garvey EP, et al. Antimicrob Agents Chemother. 2008 Mar;52(3):901-8. doi: 10.1128/AAC.01218-07. Epub 2007 Dec 26. Antimicrob Agents Chemother. 2008. PMID: 18160521 Free PMC article.
Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.
Boros EE, Edwards CE, Foster SA, Fuji M, Fujiwara T, Garvey EP, Golden PL, Hazen RJ, Jeffrey JL, Johns BA, Kawasuji T, Kiyama R, Koble CS, Kurose N, Miller WH, Mote AL, Murai H, Sato A, Thompson JB, Woodward MC, Yoshinaga T. Boros EE, et al. Among authors: garvey ep. J Med Chem. 2009 May 14;52(9):2754-61. doi: 10.1021/jm801404b. J Med Chem. 2009. PMID: 19374386
Carbamoyl pyridone HIV-1 integrase inhibitors. 2. Bi- and tricyclic derivatives result in superior antiviral and pharmacokinetic profiles.
Kawasuji T, Johns BA, Yoshida H, Weatherhead JG, Akiyama T, Taishi T, Taoda Y, Mikamiyama-Iwata M, Murai H, Kiyama R, Fuji M, Tanimoto N, Yoshinaga T, Seki T, Kobayashi M, Sato A, Garvey EP, Fujiwara T. Kawasuji T, et al. Among authors: garvey ep. J Med Chem. 2013 Feb 14;56(3):1124-35. doi: 10.1021/jm301550c. Epub 2013 Jan 22. J Med Chem. 2013. PMID: 23316884
Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).
Johns BA, Kawasuji T, Weatherhead JG, Taishi T, Temelkoff DP, Yoshida H, Akiyama T, Taoda Y, Murai H, Kiyama R, Fuji M, Tanimoto N, Jeffrey J, Foster SA, Yoshinaga T, Seki T, Kobayashi M, Sato A, Johnson MN, Garvey EP, Fujiwara T. Johns BA, et al. Among authors: garvey ep. J Med Chem. 2013 Jul 25;56(14):5901-16. doi: 10.1021/jm400645w. Epub 2013 Jul 11. J Med Chem. 2013. PMID: 23845180
85 results