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Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.
Garscha U, Romp E, Pace S, Rossi A, Temml V, Schuster D, König S, Gerstmeier J, Liening S, Werner M, Atze H, Wittmann S, Weinigel C, Rummler S, Scriba GK, Sautebin L, Werz O. Garscha U, et al. Sci Rep. 2017 Aug 24;7(1):9398. doi: 10.1038/s41598-017-09795-w. Sci Rep. 2017. PMID: 28839250 Free PMC article.
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.
Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh CP, Guilet D, Troisi F, Neukirch K, König S, Bilancia R, Waltenberger B, Stuppner H, Wallert M, Lorkowski S, Weinigel C, Rummler S, Birringer M, Roviezzo F, Sautebin L, Helesbeux JJ, Séraphin D, Mosig AS, Schuster D, Rossi A, Richomme P, Werz O, Koeberle A. Pein H, et al. Among authors: garscha u. Nat Commun. 2018 Sep 20;9(1):3834. doi: 10.1038/s41467-018-06158-5. Nat Commun. 2018. PMID: 30237488 Free PMC article.
Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159.
König S, Romp E, Krauth V, Rühl M, Dörfer M, Liening S, Hofmann B, Häfner AK, Steinhilber D, Karas M, Garscha U, Hoffmeister D, Werz O. König S, et al. Among authors: garscha u. Cell Chem Biol. 2019 Jan 17;26(1):60-70.e4. doi: 10.1016/j.chembiol.2018.10.010. Epub 2018 Nov 8. Cell Chem Biol. 2019. PMID: 30415966 Free article.
Identification of 2,4-Dinitro-Biphenyl-Based Compounds as MAPEG Inhibitors.
Di Micco S, Terracciano S, Pierri M, Cantone V, Liening S, König S, Garscha U, Hofstetter RK, Koeberle A, Werz O, Bruno I, Bifulco G. Di Micco S, et al. Among authors: garscha u. ChemMedChem. 2022 Nov 18;17(22):e202200327. doi: 10.1002/cmdc.202200327. Epub 2022 Oct 11. ChemMedChem. 2022. PMID: 36111583 Free PMC article.
Novel thiazolopyridine derivatives of diflapolin as dual sEH/FLAP inhibitors with improved solubility.
Schoenthaler M, Waltl L, Hasenoehrl T, Seher D, Lutz A, Aulinger L, Temml V, König S, Siller A, Braun DE, Garscha U, Werz O, Schuster D, Schennach H, Koeberle A, Matuszczak B. Schoenthaler M, et al. Among authors: garscha u. Bioorg Chem. 2023 Oct;139:106685. doi: 10.1016/j.bioorg.2023.106685. Epub 2023 Jun 28. Bioorg Chem. 2023. PMID: 37418786 Free article.
12-Oxo-10-glutathionyl-5,8,14-eicosatrienoic acid (TOG10), a novel glutathione-containing eicosanoid generated via the 12-lipoxygenase pathway in human platelets.
Liening S, Fischer J, Jagusch H, Pohnert G, Höcker O, Neusüß C, Werz O, Scriba GKE, Garscha U. Liening S, et al. Among authors: garscha u. Prostaglandins Other Lipid Mediat. 2021 Feb;152:106480. doi: 10.1016/j.prostaglandins.2020.106480. Epub 2020 Oct 22. Prostaglandins Other Lipid Mediat. 2021. PMID: 33172790
56 results