Garscha U - Search Results

1

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.

Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh CP, Guilet D, Troisi F, Neukirch K, König S, Bilancia R, Waltenberger B, Stuppner H, Wallert M, Lorkowski S, Weinigel C, Rummler S, Birringer M, Roviezzo F, Sautebin L, Helesbeux JJ, Séraphin D, Mosig AS, Schuster D, Rossi A, Richomme P, Werz O, Koeberle A. Pein H, et al. Among authors: garscha u. Nat Commun. 2018 Sep 20;9(1):3834. doi: 10.1038/s41467-018-06158-5. Nat Commun. 2018. PMID: 30237488 Free PMC article.

2

Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.

Pergola C, Gaboriaud-Kolar N, Jestädt N, König S, Kritsanida M, Schaible AM, Li H, Garscha U, Weinigel C, Barz D, Albring KF, Huber O, Skaltsounis AL, Werz O. Pergola C, et al. Among authors: garscha u. J Med Chem. 2014 May 8;57(9):3715-23. doi: 10.1021/jm401740w. Epub 2014 Apr 17. J Med Chem. 2014. PMID: 24697244

3

An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis.

Gerstmeier J, Weinigel C, Barz D, Werz O, Garscha U. Gerstmeier J, et al. Among authors: garscha u. Biochim Biophys Acta. 2014 Sep;1840(9):2961-9. doi: 10.1016/j.bbagen.2014.05.016. Epub 2014 Jun 4. Biochim Biophys Acta. 2014. PMID: 24905297

4

A procedure for efficient non-viral siRNA transfection of primary human monocytes using nucleofection.

Scherer O, Maeß MB, Lindner S, Garscha U, Weinigel C, Rummler S, Werz O, Lorkowski S. Scherer O, et al. Among authors: garscha u. J Immunol Methods. 2015 Jul;422:118-24. doi: 10.1016/j.jim.2015.04.007. Epub 2015 Apr 17. J Immunol Methods. 2015. PMID: 25891792

5

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol.

Noha SM, Fischer K, Koeberle A, Garscha U, Werz O, Schuster D. Noha SM, et al. Among authors: garscha u. Bioorg Med Chem. 2015 Aug 1;23(15):4839-4845. doi: 10.1016/j.bmc.2015.05.045. Epub 2015 Jun 1. Bioorg Med Chem. 2015. PMID: 26088337 Free PMC article.

6

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.

De Lucia D, Lucio OM, Musio B, Bender A, Listing M, Dennhardt S, Koeberle A, Garscha U, Rizzo R, Manfredini S, Werz O, Ley SV. De Lucia D, et al. Among authors: garscha u. Eur J Med Chem. 2015 Aug 28;101:573-83. doi: 10.1016/j.ejmech.2015.07.011. Epub 2015 Jul 15. Eur J Med Chem. 2015. PMID: 26197161

7

Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP.

Häfner AK, Gerstmeier J, Hörnig M, George S, Ball AK, Schröder M, Garscha U, Werz O, Steinhilber D. Häfner AK, et al. Among authors: garscha u. Biochim Biophys Acta. 2015 Nov;1851(11):1465-72. doi: 10.1016/j.bbalip.2015.08.010. Epub 2015 Aug 29. Biochim Biophys Acta. 2015. PMID: 26327594

8

Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes.

Gerstmeier J, Weinigel C, Rummler S, Rådmark O, Werz O, Garscha U. Gerstmeier J, et al. Among authors: garscha u. FASEB J. 2016 Jan;30(1):276-85. doi: 10.1096/fj.15-278010. Epub 2015 Sep 22. FASEB J. 2016. PMID: 26396238

9

5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation.

Gerstmeier J, Newcomer ME, Dennhardt S, Romp E, Fischer J, Werz O, Garscha U. Gerstmeier J, et al. Among authors: garscha u. FASEB J. 2016 May;30(5):1892-900. doi: 10.1096/fj.201500210R. Epub 2016 Feb 3. FASEB J. 2016. PMID: 26842853 Free PMC article.

., Newcomer, M. E., Dennhardt, S., Romp, E., Fischer, J., Werz, O., Garscha, U. 5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation....

., Newcomer, M. E., Dennhardt, S., Romp, E., Fischer, J., Werz, O., Garscha, U. 5-Lipoxygenase-activating protein rescues acti …

10

Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening.

Waltenberger B, Garscha U, Temml V, Liers J, Werz O, Schuster D, Stuppner H. Waltenberger B, et al. Among authors: garscha u. J Chem Inf Model. 2016 Apr 25;56(4):747-62. doi: 10.1021/acs.jcim.5b00592. Epub 2016 Apr 4. J Chem Inf Model. 2016. PMID: 26882208

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