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Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer.
Hughson AL, Hannon G, Salama NA, Vrooman TG, Stockwell CA, Mills BN, Garrett-Larsen J, Qiu H, Katerji R, Benoodt L, Johnston CJ, Murphy JD, Kruger E, Ye J, Gavras NW, Keeley DC, Qin SS, Lesch ML, Muhitch JB, Love TMT, Calvi LM, Lord EM, Luheshi N, Elyes J, Linehan DC, Gerber SA. Hughson AL, et al. Among authors: garrett larsen j. bioRxiv [Preprint]. 2023 Nov 2:2023.10.30.564833. doi: 10.1101/2023.10.30.564833. bioRxiv. 2023. PMID: 37961513 Free PMC article. Preprint.
New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy.
Uccello TP, Lesch ML, Kintzel SA, Gradzewicz LB, Lamrous L, Murphy SP, Fleming FJ, Mills BN, Murphy JD, Hughson A, Hannon G, Garrett-Larsen J, Qiu H, Drage MG, Ye J, Gavras NW, Keeley DC, Love TMT, Repasky EA, Lord EM, Linehan DC, Gerber SA. Uccello TP, et al. Among authors: garrett larsen j. Cell Death Dis. 2023 Jul 26;14(7):470. doi: 10.1038/s41419-023-05999-3. Cell Death Dis. 2023. PMID: 37495596 Free PMC article.
New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy.
Gerber S, Uccello T, Lesch M, Kintzel S, Gradzewicz L, Lamrous L, Murphy S, Fleming F, Mills B, Murphy J, Hughson A, Garrett-Larsen J, Qiu H, Drage M, Ye J, Gavras N, Keeley D, Love T, Repasky E, Lord E, Linehan D. Gerber S, et al. Among authors: garrett larsen j. Res Sq [Preprint]. 2023 Apr 13:rs.3.rs-2767780. doi: 10.21203/rs.3.rs-2767780/v1. Res Sq. 2023. PMID: 37090639 Free PMC article. Updated. Preprint.
Radiation Therapy Exacerbates Tumor-Promoting Innervation and Nerve Signaling in Rectal Cancer.
Uccello TP, Lesch ML, Ullman NA, Kintzel SA, Gradzewicz LB, Velagaleti T, Fleming FJ, Mills BN, Murphy JD, Garrett-Larsen J, Qiu H, Drage MG, Ye J, Gavras NW, Johnston CJ, Love TMT, Repasky EA, Linehan DC, Lord EM, Gerber SA. Uccello TP, et al. Among authors: garrett larsen j. Int J Radiat Oncol Biol Phys. 2023 Mar 1;115(3):733-745. doi: 10.1016/j.ijrobp.2022.09.080. Epub 2022 Oct 4. Int J Radiat Oncol Biol Phys. 2023. PMID: 36202180 Free PMC article.
Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer.
Ye J, Mills BN, Qin SS, Garrett-Larsen J, Murphy JD, Uccello TP, Han BJ, Vrooman TG, Johnston CJ, Lord EM, Belt BA, Linehan DC, Gerber SA. Ye J, et al. Among authors: garrett larsen j. J Immunother Cancer. 2022 Jul;10(7):e004784. doi: 10.1136/jitc-2022-004784. J Immunother Cancer. 2022. PMID: 35851308 Free PMC article.
Development of an Orthotopic Murine Model of Rectal Cancer in Conjunction With Targeted Short-Course Radiation Therapy.
Uccello TP, Kintzel SA, Mills BN, Murphy JD, Garrett-Larsen J, Battaglia NG, Rodriguez CJ, Drage MG, Ye J, Love TMT, Johnston CJ, Repasky EA, Qiu H, Linehan DC, Lord EM, Gerber SA. Uccello TP, et al. Among authors: garrett larsen j. Adv Radiat Oncol. 2021 Dec 9;7(2):100867. doi: 10.1016/j.adro.2021.100867. eCollection 2022 Mar-Apr. Adv Radiat Oncol. 2021. PMID: 35036637 Free PMC article.
Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy.
Mills BN, Qiu H, Drage MG, Chen C, Mathew JS, Garrett-Larsen J, Ye J, Uccello TP, Murphy JD, Belt BA, Lord EM, Katz AW, Linehan DC, Gerber SA. Mills BN, et al. Among authors: garrett larsen j. Clin Cancer Res. 2022 Jan 1;28(1):150-162. doi: 10.1158/1078-0432.CCR-21-2495. Epub 2021 Dec 3. Clin Cancer Res. 2022. PMID: 34862242 Free PMC article.
Coadministration of a Clinically Relevant Dexamethasone Dosage With Ablative Radiation Therapy Reduces Peripheral Lymphocytes But Does Not Alter In Vivo Intratumoral Lymphocyte Phenotype or Inhibit Efficacy of Radiation Therapy in a Murine Colorectal Tumor Model.
Battaglia NG, Uccello TP, Hughson A, Garrett-Larsen J, Caldon JJ, Qiu H, Gerber SA, Lord EM. Battaglia NG, et al. Among authors: garrett larsen j. Int J Radiat Oncol Biol Phys. 2021 Sep 1;111(1):284-296. doi: 10.1016/j.ijrobp.2021.04.021. Epub 2021 Apr 30. Int J Radiat Oncol Biol Phys. 2021. PMID: 33933481 Free PMC article.