Garrett MD - Search Results

1

Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling.

Stockwell SR, Platt G, Barrie SE, Zoumpoulidou G, Te Poele RH, Aherne GW, Wilson SC, Sheldrake P, McDonald E, Venet M, Soudy C, Elustondo F, Rigoreau L, Blagg J, Workman P, Garrett MD, Mittnacht S. Stockwell SR, et al. Among authors: garrett md. PLoS One. 2012;7(1):e28568. doi: 10.1371/journal.pone.0028568. Epub 2012 Jan 12. PLoS One. 2012. PMID: 22253692 Free PMC article.

2

Discovering novel chemotherapeutic drugs for the third millennium.

Garrett MD, Workman P. Garrett MD, et al. Eur J Cancer. 1999 Dec;35(14):2010-30. doi: 10.1016/s0959-8049(99)00280-4. Eur J Cancer. 1999. PMID: 10711243 Review.

3

High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.

Barrie SE, Eno-Amooquaye E, Hardcastle A, Platt G, Richards J, Bedford D, Workman P, Aherne W, Mittnacht S, Garrett MD. Barrie SE, et al. Among authors: garrett md. Anal Biochem. 2003 Sep 1;320(1):66-74. doi: 10.1016/s0003-2697(03)00349-x. Anal Biochem. 2003. PMID: 12895470

4

The contemporary drug development process: advances and challenges in preclinical and clinical development.

Garrett MD, Walton MI, McDonald E, Judson I, Workman P. Garrett MD, et al. Prog Cell Cycle Res. 2003;5:145-58. Prog Cell Cycle Res. 2003. PMID: 14593708 Review.

5

The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.

Whittaker SR, Walton MI, Garrett MD, Workman P. Whittaker SR, et al. Among authors: garrett md. Cancer Res. 2004 Jan 1;64(1):262-72. doi: 10.1158/0008-5472.can-03-0110. Cancer Res. 2004. PMID: 14729633

6

Clinical anticancer drug development: targeting the cyclin-dependent kinases.

Benson C, Kaye S, Workman P, Garrett M, Walton M, de Bono J. Benson C, et al. Br J Cancer. 2005 Jan 17;92(1):7-12. doi: 10.1038/sj.bjc.6602229. Br J Cancer. 2005. PMID: 15558073 Free PMC article. Review.

7

In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.

Raynaud FI, Whittaker SR, Fischer PM, McClue S, Walton MI, Barrie SE, Garrett MD, Rogers P, Clarke SJ, Kelland LR, Valenti M, Brunton L, Eccles S, Lane DP, Workman P. Raynaud FI, et al. Among authors: garrett md. Clin Cancer Res. 2005 Jul 1;11(13):4875-87. doi: 10.1158/1078-0432.CCR-04-2264. Clin Cancer Res. 2005. PMID: 16000586

8

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B.

Collins I, Caldwell J, Fonseca T, Donald A, Bavetsias V, Hunter LJ, Garrett MD, Rowlands MG, Aherne GW, Davies TG, Berdini V, Woodhead SJ, Davis D, Seavers LC, Wyatt PG, Workman P, McDonald E. Collins I, et al. Among authors: garrett md. Bioorg Med Chem. 2006 Feb 15;14(4):1255-73. doi: 10.1016/j.bmc.2005.09.055. Epub 2005 Oct 24. Bioorg Med Chem. 2006. PMID: 16249095

9

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.

Oliver AW, Paul A, Boxall KJ, Barrie SE, Aherne GW, Garrett MD, Mittnacht S, Pearl LH. Oliver AW, et al. Among authors: garrett md. EMBO J. 2006 Jul 12;25(13):3179-90. doi: 10.1038/sj.emboj.7601209. Epub 2006 Jun 22. EMBO J. 2006. PMID: 16794575 Free PMC article.

10

Identification of small-molecule inhibitors of protein kinase B (PKB/AKT) in an AlphaScreenTM high-throughput screen.

Burns S, Travers J, Collins I, Rowlands MG, Newbatt Y, Thompson N, Garrett MD, Workman P, Aherne W. Burns S, et al. Among authors: garrett md. J Biomol Screen. 2006 Oct;11(7):822-7. doi: 10.1177/1087057106290992. Epub 2006 Aug 10. J Biomol Screen. 2006. PMID: 16902245

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