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A novel anti-viral role for STAT3 in IFN-α signalling responses.
Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ. Mahony R, et al. Among authors: gargan s. Cell Mol Life Sci. 2017 May;74(9):1755-1764. doi: 10.1007/s00018-016-2435-3. Epub 2016 Dec 17. Cell Mol Life Sci. 2017. PMID: 27988795 Free PMC article.
The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)-α via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK)-mediated induction of suppressor of cytokine signaling (SOCS)3.
Convery O, Gargan S, Kickham M, Schroder M, O'Farrelly C, Stevenson NJ. Convery O, et al. Among authors: gargan s. FASEB J. 2019 Aug;33(8):8732-8744. doi: 10.1096/fj.201800629RR. Epub 2019 Jun 4. FASEB J. 2019. PMID: 31163989
Here we show that the HCV protein, p7, enhances both SOCS3 mRNA and protein expression. A p7 inhibitor reduced SOCS3 induction, indicating that p7's ion channel activity was required for optimal up-regulation of SOCS3. ...Together, these findings identify a molecular mecha …
Here we show that the HCV protein, p7, enhances both SOCS3 mRNA and protein expression. A p7 inhibitor reduced SOCS3 induction, indicating t …
Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15.
Doyle SL, Shirey KA, McGettrick AF, Kenny EF, Carpenter S, Caffrey BE, Gargan S, Quinn SR, Caamaño JH, Moynagh P, Vogel SN, O'Neill LA. Doyle SL, et al. Among authors: gargan s. J Biol Chem. 2013 Aug 30;288(35):25066-25075. doi: 10.1074/jbc.M113.469122. Epub 2013 Jul 19. J Biol Chem. 2013. PMID: 23873932 Free PMC article.
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, Brien ECO, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, Donnell JSO, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ. Ryan TAJ, et al. Among authors: gargan s. Nat Commun. 2023 Jun 14;14(1):3513. doi: 10.1038/s41467-023-39174-1. Nat Commun. 2023. PMID: 37316487 Free PMC article.
34 results