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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Vervoort SJ, Welsh SA, Devlin JR, Barbieri E, Knight DA, Offley S, Bjelosevic S, Costacurta M, Todorovski I, Kearney CJ, Sandow JJ, Fan Z, Blyth B, McLeod V, Vissers JHA, Pavic K, Martin BP, Gregory G, Demosthenous E, Zethoven M, Kong IY, Hawkins ED, Hogg SJ, Kelly MJ, Newbold A, Simpson KJ, Kauko O, Harvey KF, Ohlmeyer M, Westermarck J, Gray N, Gardini A, Johnstone RW. Vervoort SJ, et al. Among authors: gardini a. Cell. 2021 Jun 10;184(12):3143-3162.e32. doi: 10.1016/j.cell.2021.04.022. Epub 2021 May 17. Cell. 2021. PMID: 34004147 Free PMC article.
Targeted Enhancer Activation by a Subunit of the Integrator Complex.
Barbieri E, Trizzino M, Welsh SA, Owens TA, Calabretta B, Carroll M, Sarma K, Gardini A. Barbieri E, et al. Among authors: gardini a. Mol Cell. 2018 Jul 5;71(1):103-116.e7. doi: 10.1016/j.molcel.2018.05.031. Epub 2018 Jun 28. Mol Cell. 2018. PMID: 30008316 Free PMC article.
Rapid and Scalable Profiling of Nascent RNA with fastGRO.
Barbieri E, Hill C, Quesnel-Vallières M, Zucco AJ, Barash Y, Gardini A. Barbieri E, et al. Among authors: gardini a. Cell Rep. 2020 Nov 10;33(6):108373. doi: 10.1016/j.celrep.2020.108373. Cell Rep. 2020. PMID: 33176136 Free PMC article.
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages.
Trizzino M, Zucco A, Deliard S, Wang F, Barbieri E, Veglia F, Gabrilovich D, Gardini A. Trizzino M, et al. Among authors: gardini a. Sci Adv. 2021 Jan 13;7(3):eaaz8836. doi: 10.1126/sciadv.aaz8836. Print 2021 Jan. Sci Adv. 2021. PMID: 33523892 Free PMC article.
A combinatorial approach to uncover an additional Integrator subunit.
Offley SR, Pfleiderer MM, Zucco A, Fraudeau A, Welsh SA, Razew M, Galej WP, Gardini A. Offley SR, et al. Among authors: gardini a. Cell Rep. 2023 Mar 28;42(3):112244. doi: 10.1016/j.celrep.2023.112244. Epub 2023 Mar 14. Cell Rep. 2023. PMID: 36920904 Free PMC article.
G-quadruplexes associated with R-loops promote CTCF binding.
Wulfridge P, Yan Q, Rell N, Doherty J, Jacobson S, Offley S, Deliard S, Feng K, Phillips-Cremins JE, Gardini A, Sarma K. Wulfridge P, et al. Among authors: gardini a. Mol Cell. 2023 Sep 7;83(17):3064-3079.e5. doi: 10.1016/j.molcel.2023.07.009. Epub 2023 Aug 7. Mol Cell. 2023. PMID: 37552993
Long noncoding RNAs with enhancer-like function in human cells.
Ørom UA, Derrien T, Beringer M, Gumireddy K, Gardini A, Bussotti G, Lai F, Zytnicki M, Notredame C, Huang Q, Guigo R, Shiekhattar R. Ørom UA, et al. Among authors: gardini a. Cell. 2010 Oct 1;143(1):46-58. doi: 10.1016/j.cell.2010.09.001. Cell. 2010. PMID: 20887892 Free PMC article.
143 results