Garcia-Marcos M - Search Results

1

Hsp70-Bag3 interactions regulate cancer-related signaling networks.

Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, Takayama S, Sherman MY. Colvin TA, et al. Cancer Res. 2014 Sep 1;74(17):4731-40. doi: 10.1158/0008-5472.CAN-14-0747. Epub 2014 Jul 3. Cancer Res. 2014. PMID: 24994713 Free PMC article.

2

Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin.

Leyme A, Marivin A, Perez-Gutierrez L, Nguyen LT, Garcia-Marcos M. Leyme A, et al. J Cell Biol. 2015 Sep 28;210(7):1165-84. doi: 10.1083/jcb.201506041. Epub 2015 Sep 21. J Cell Biol. 2015. PMID: 26391662 Free PMC article.

3

GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells.

Leyme A, Marivin A, Garcia-Marcos M. Leyme A, et al. J Biol Chem. 2016 Apr 8;291(15):8269-82. doi: 10.1074/jbc.M115.691550. Epub 2016 Feb 17. J Biol Chem. 2016. PMID: 26887938 Free PMC article.

4

Probing the mutational landscape of regulators of G protein signaling proteins in cancer.

DiGiacomo V, Maziarz M, Luebbers A, Norris JM, Laksono P, Garcia-Marcos M. DiGiacomo V, et al. Sci Signal. 2020 Feb 4;13(617):eaax8620. doi: 10.1126/scisignal.aax8620. Sci Signal. 2020. PMID: 32019900 Free PMC article.

5

A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.

Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, Ear J, Jung BH, Cabrera B, Carethers JM, Farquhar MG. Ghosh P, et al. Mol Biol Cell. 2010 Jul 1;21(13):2338-54. doi: 10.1091/mbc.e10-01-0028. Epub 2010 May 12. Mol Biol Cell. 2010. PMID: 20462955 Free PMC article.

6

A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals.

Garcia-Marcos M, Ear J, Farquhar MG, Ghosh P. Garcia-Marcos M, et al. Mol Biol Cell. 2011 Mar 1;22(5):673-86. doi: 10.1091/mbc.E10-08-0738. Epub 2011 Jan 5. Mol Biol Cell. 2011. PMID: 21209316 Free PMC article.

7

Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling.

Garcia-Marcos M, Kietrsunthorn PS, Pavlova Y, Adia MA, Ghosh P, Farquhar MG. Garcia-Marcos M, et al. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1961-6. doi: 10.1073/pnas.1120538109. Epub 2012 Jan 25. Proc Natl Acad Sci U S A. 2012. PMID: 22308453 Free PMC article.

8

Gαs promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin).

Beas AO, Taupin V, Teodorof C, Nguyen LT, Garcia-Marcos M, Farquhar MG. Beas AO, et al. Mol Biol Cell. 2012 Dec;23(23):4623-34. doi: 10.1091/mbc.E12-02-0133. Epub 2012 Oct 10. Mol Biol Cell. 2012. PMID: 23051738 Free PMC article.

9

Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein.

Leyme A, Marivin A, Maziarz M, DiGiacomo V, Papakonstantinou MP, Patel PP, Blanco-Canosa JB, Walawalkar IA, Rodriguez-Davila G, Dominguez I, Garcia-Marcos M. Leyme A, et al. Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10319-E10328. doi: 10.1073/pnas.1707992114. Epub 2017 Nov 13. Proc Natl Acad Sci U S A. 2017. PMID: 29133411 Free PMC article.

10

Naturally occurring hotspot cancer mutations in Gα₁₃ promote oncogenic signaling.

Maziarz M, Federico A, Zhao J, Dujmusic L, Zhao Z, Monti S, Varelas X, Garcia-Marcos M. Maziarz M, et al. J Biol Chem. 2020 Dec 4;295(49):16897-16904. doi: 10.1074/jbc.AC120.014698. Epub 2020 Oct 27. J Biol Chem. 2020. PMID: 33109615 Free PMC article.

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