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Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies.
Slatter DA, Percy CL, Allen-Redpath K, Gajsiewicz JM, Brooks NJ, Clayton A, Tyrrell VJ, Rosas M, Lauder SN, Watson A, Dul M, Garcia-Diaz Y, Aldrovandi M, Heurich M, Hall J, Morrissey JH, Lacroix-Desmazes S, Delignat S, Jenkins PV, Collins PW, O'Donnell VB. Slatter DA, et al. Among authors: garcia diaz y. JCI Insight. 2018 Mar 22;3(6):e98459. doi: 10.1172/jci.insight.98459. JCI Insight. 2018. PMID: 29563336 Free PMC article.
Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ.
Hammond VJ, Morgan AH, Lauder S, Thomas CP, Brown S, Freeman BA, Lloyd CM, Davies J, Bush A, Levonen AL, Kansanen E, Villacorta L, Chen YE, Porter N, Garcia-Diaz YM, Schopfer FJ, O'Donnell VB. Hammond VJ, et al. Among authors: garcia diaz ym. J Biol Chem. 2012 Dec 7;287(50):41651-66. doi: 10.1074/jbc.M112.405407. Epub 2012 Oct 11. J Biol Chem. 2012. PMID: 23060450 Free PMC article. Clinical Trial.
Design, synthesis, and functional activity of labeled CD1d glycolipid agonists.
Jervis PJ, Polzella P, Wojno J, Jukes JP, Ghadbane H, Garcia Diaz YR, Besra GS, Cerundolo V, Cox LR. Jervis PJ, et al. Among authors: garcia diaz yr. Bioconjug Chem. 2013 Apr 17;24(4):586-94. doi: 10.1021/bc300556e. Epub 2013 Mar 19. Bioconjug Chem. 2013. PMID: 23458425 Free PMC article.
Quantitative assays for esterified oxylipins generated by immune cells.
Morgan AH, Hammond VJ, Morgan L, Thomas CP, Tallman KA, Garcia-Diaz YR, McGuigan C, Serpi M, Porter NA, Murphy RC, O'Donnell VB. Morgan AH, et al. Among authors: garcia diaz yr. Nat Protoc. 2010 Dec;5(12):1919-31. doi: 10.1038/nprot.2010.162. Epub 2010 Nov 10. Nat Protoc. 2010. PMID: 21127486 Free PMC article.