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CEBPA phase separation links transcriptional activity and 3D chromatin hubs.
Christou-Kent M, Cuartero S, Garcia-Cabau C, Ruehle J, Naderi J, Erber J, Neguembor MV, Plana-Carmona M, Alcoverro-Bertran M, De Andres-Aguayo L, Klonizakis A, Julià-Vilella E, Lynch C, Serrano M, Hnisz D, Salvatella X, Graf T, Stik G. Christou-Kent M, et al. Among authors: garcia cabau c. Cell Rep. 2023 Aug 29;42(8):112897. doi: 10.1016/j.celrep.2023.112897. Epub 2023 Jul 29. Cell Rep. 2023. PMID: 37516962 Free article.
A glutamine-based single α-helix scaffold to target globular proteins.
Escobedo A, Piccirillo J, Aranda J, Diercks T, Mateos B, Garcia-Cabau C, Sánchez-Navarro M, Topal B, Biesaga M, Staby L, Kragelund BB, García J, Millet O, Orozco M, Coles M, Crehuet R, Salvatella X. Escobedo A, et al. Among authors: garcia cabau c. Nat Commun. 2022 Nov 18;13(1):7073. doi: 10.1038/s41467-022-34793-6. Nat Commun. 2022. PMID: 36400768 Free PMC article.
Aberrant phase separation and nucleolar dysfunction in rare genetic diseases.
Mensah MA, Niskanen H, Magalhaes AP, Basu S, Kircher M, Sczakiel HL, Reiter AMV, Elsner J, Meinecke P, Biskup S, Chung BHY, Dombrowsky G, Eckmann-Scholz C, Hitz MP, Hoischen A, Holterhus PM, Hülsemann W, Kahrizi K, Kalscheuer VM, Kan A, Krumbiegel M, Kurth I, Leubner J, Longardt AC, Moritz JD, Najmabadi H, Skipalova K, Snijders Blok L, Tzschach A, Wiedersberg E, Zenker M, Garcia-Cabau C, Buschow R, Salvatella X, Kraushar ML, Mundlos S, Caliebe A, Spielmann M, Horn D, Hnisz D. Mensah MA, et al. Among authors: garcia cabau c. Nature. 2023 Feb;614(7948):564-571. doi: 10.1038/s41586-022-05682-1. Epub 2023 Feb 8. Nature. 2023. PMID: 36755093 Free PMC article.
A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing.
Sanfeliu-Cerdán N, Català-Castro F, Mateos B, Garcia-Cabau C, Ribera M, Ruider I, Porta-de-la-Riva M, Canals-Calderón A, Wieser S, Salvatella X, Krieg M. Sanfeliu-Cerdán N, et al. Among authors: garcia cabau c. Nat Cell Biol. 2023 Nov;25(11):1590-1599. doi: 10.1038/s41556-023-01247-0. Epub 2023 Oct 19. Nat Cell Biol. 2023. PMID: 37857834 Free PMC article.
Rational optimization of a transcription factor activation domain inhibitor.
Basu S, Martínez-Cristóbal P, Frigolé-Vivas M, Pesarrodona M, Lewis M, Szulc E, Bañuelos CA, Sánchez-Zarzalejo C, Bielskutė S, Zhu J, Pombo-García K, Garcia-Cabau C, Zodi L, Dockx H, Smak J, Kaur H, Batlle C, Mateos B, Biesaga M, Escobedo A, Bardia L, Verdaguer X, Ruffoni A, Mawji NR, Wang J, Obst JK, Tam T, Brun-Heath I, Ventura S, Meierhofer D, García J, Robustelli P, Stracker TH, Sadar MD, Riera A, Hnisz D, Salvatella X. Basu S, et al. Among authors: garcia cabau c. Nat Struct Mol Biol. 2023 Dec;30(12):1958-1969. doi: 10.1038/s41594-023-01159-5. Epub 2023 Dec 4. Nat Struct Mol Biol. 2023. PMID: 38049566 Free PMC article.
Common pathophysiology for ANXA11 disorders caused by aspartate 40 variants.
Natera-de Benito D, Olival J, Garcia-Cabau C, Jou C, Roldan M, Codina A, Expósito-Escudero J, Batlle C, Carrera-García L, Ortez C, Salvatella X, Palau F, Nascimento A, Hoenicka J. Natera-de Benito D, et al. Among authors: garcia cabau c. Ann Clin Transl Neurol. 2023 Mar;10(3):408-425. doi: 10.1002/acn3.51731. Epub 2023 Jan 18. Ann Clin Transl Neurol. 2023. PMID: 36651622 Free PMC article.
Sorting of secretory proteins at the trans-Golgi network by human TGN46.
Lujan P, Garcia-Cabau C, Wakana Y, Vera Lillo J, Rodilla-Ramírez C, Sugiura H, Malhotra V, Salvatella X, Garcia-Parajo MF, Campelo F. Lujan P, et al. Among authors: garcia cabau c. Elife. 2024 Mar 11;12:RP91708. doi: 10.7554/eLife.91708. Elife. 2024. PMID: 38466628 Free PMC article.