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Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo.
Ramos TL, Bolivar-Wagers S, Jin S, Thangavelu G, Simonetta F, Lin PY, Hirai T, Saha A, Koehn B, Su LL, Picton LK, Baker J, Lohmeyer JK, Riddle M, Eide C, Tolar J, Panoskaltsis-Mortari A, Wagner JE, Garcia KC, Negrin RS, Blazar BR. Ramos TL, et al. Among authors: garcia kc. Blood. 2023 Mar 16;141(11):1337-1352. doi: 10.1182/blood.2022018440. Blood. 2023. PMID: 36564052 Free PMC article.
Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure.
Beltra JC, Abdel-Hakeem MS, Manne S, Zhang Z, Huang H, Kurachi M, Su L, Picton L, Ngiow SF, Muroyama Y, Casella V, Huang YJ, Giles JR, Mathew D, Belman J, Klapholz M, Decaluwe H, Huang AC, Berger SL, Garcia KC, Wherry EJ. Beltra JC, et al. Among authors: garcia kc. Immunity. 2023 Dec 12;56(12):2699-2718.e11. doi: 10.1016/j.immuni.2023.11.005. Immunity. 2023. PMID: 38091951
Structural insights into human MHC-II association with invariant chain.
Wang N, Waghray D, Caveney NA, Jude KM, Garcia KC. Wang N, et al. Among authors: garcia kc. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2403031121. doi: 10.1073/pnas.2403031121. Epub 2024 Apr 30. Proc Natl Acad Sci U S A. 2024. PMID: 38687785 Free article.
Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling.
Caveney NA, Rodriguez GE, Pollmann C, Meyer T, Borowska MT, Wilson SC, Wang N, Xiang X, Householder KD, Tao P, Su LL, Saxton RA, Piehler J, Garcia KC. Caveney NA, et al. Among authors: garcia kc. Mol Cell. 2024 Apr 5:S1097-2765(24)00268-5. doi: 10.1016/j.molcel.2024.03.023. Online ahead of print. Mol Cell. 2024. PMID: 38614096 Free article.
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Zihsler S, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF. Martinez HA, et al. Among authors: garcia kc. Nat Commun. 2024 Feb 20;15(1):1564. doi: 10.1038/s41467-024-45012-9. Nat Commun. 2024. PMID: 38378682 Free PMC article.
A general platform for targeting MHC-II antigens via a single loop.
Du H, Liu J, Jude KM, Yang X, Li Y, Bell B, Yang H, Kassardjian A, Mobedi A, Parekh U, Sperberg RAP, Julien JP, Mellins ED, Garcia KC, Huang PS. Du H, et al. Among authors: garcia kc. bioRxiv [Preprint]. 2024 Jan 30:2024.01.26.577489. doi: 10.1101/2024.01.26.577489. bioRxiv. 2024. PMID: 38352315 Free PMC article. Preprint.
IL-2-induced Stat3 Signaling is Critical for Effector Treg Cell Programming.
Dean EC, Ditoro DF, Pham D, Gao M, Zindl CL, Frey B, Harbour SN, Figge DA, Miller AT, Glassman CR, Garcia KC, Hatton RD, Weaver CT. Dean EC, et al. Among authors: garcia kc. bioRxiv [Preprint]. 2023 Sep 28:2023.09.26.559434. doi: 10.1101/2023.09.26.559434. bioRxiv. 2023. PMID: 37808649 Free PMC article. Preprint.
298 results