Garcia KC - Search Results

1

Emerging principles of cytokine pharmacology and therapeutics.

Saxton RA, Glassman CR, Garcia KC. Saxton RA, et al. Among authors: garcia kc. Nat Rev Drug Discov. 2023 Jan;22(1):21-37. doi: 10.1038/s41573-022-00557-6. Epub 2022 Sep 21. Nat Rev Drug Discov. 2023. PMID: 36131080 Free PMC article. Review.

2

Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro.

Gee MH, Sibener LV, Birnbaum ME, Jude KM, Yang X, Fernandes RA, Mendoza JL, Glassman CR, Garcia KC. Gee MH, et al. Among authors: garcia kc. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7369-E7378. doi: 10.1073/pnas.1802746115. Epub 2018 Jul 18. Proc Natl Acad Sci U S A. 2018. PMID: 30021852 Free PMC article.

3

Structure of the IFNγ receptor complex guides design of biased agonists.

Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC. Mendoza JL, et al. Among authors: garcia kc. Nature. 2019 Mar;567(7746):56-60. doi: 10.1038/s41586-019-0988-7. Epub 2019 Feb 27. Nature. 2019. PMID: 30814731 Free PMC article.

4

Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.

Mohan K, Ueda G, Kim AR, Jude KM, Fallas JA, Guo Y, Hafer M, Miao Y, Saxton RA, Piehler J, Sankaran VG, Baker D, Garcia KC. Mohan K, et al. Among authors: garcia kc. Science. 2019 May 24;364(6442):eaav7532. doi: 10.1126/science.aav7532. Epub 2019 May 23. Science. 2019. PMID: 31123111 Free PMC article.

5

Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch.

De Paula VS, Jude KM, Nerli S, Glassman CR, Garcia KC, Sgourakis NG. De Paula VS, et al. Among authors: garcia kc. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7183-7192. doi: 10.1073/pnas.2000419117. Epub 2020 Mar 17. Proc Natl Acad Sci U S A. 2020. PMID: 32184322 Free PMC article.

6

Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo.

Fernandes RA, Li C, Wang G, Yang X, Savvides CS, Glassman CR, Dong S, Luxenberg E, Sibener LV, Birnbaum ME, Benoist C, Mathis D, Garcia KC. Fernandes RA, et al. Among authors: garcia kc. Elife. 2020 Aug 10;9:e58463. doi: 10.7554/eLife.58463. Elife. 2020. PMID: 32773038 Free PMC article.

7

Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.

Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, Spangler JB, Ely LK, Thomas C, Skiniotis G, Garcia KC. Glassman CR, et al. Among authors: garcia kc. Cell. 2021 Feb 18;184(4):983-999.e24. doi: 10.1016/j.cell.2021.01.018. Cell. 2021. PMID: 33606986 Free PMC article.

8

Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.

Saxton RA, Tsutsumi N, Su LL, Abhiraman GC, Mohan K, Henneberg LT, Aduri NG, Gati C, Garcia KC. Saxton RA, et al. Among authors: garcia kc. Science. 2021 Mar 19;371(6535):eabc8433. doi: 10.1126/science.abc8433. Science. 2021. PMID: 33737461 Free PMC article.

9

The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design.

Saxton RA, Henneberg LT, Calafiore M, Su L, Jude KM, Hanash AM, Garcia KC. Saxton RA, et al. Among authors: garcia kc. Immunity. 2021 Apr 13;54(4):660-672.e9. doi: 10.1016/j.immuni.2021.03.008. Immunity. 2021. PMID: 33852830 Free PMC article.

10

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.

Glassman CR, Su L, Majri-Morrison SS, Winkelmann H, Mo F, Li P, Pérez-Cruz M, Ho PP, Koliesnik I, Nagy N, Hnizdilova T, Picton LK, Kovar M, Bollyky P, Steinman L, Meyer E, Piehler J, Leonard WJ, Garcia KC. Glassman CR, et al. Among authors: garcia kc. Elife. 2021 May 18;10:e65777. doi: 10.7554/eLife.65777. Elife. 2021. PMID: 34003116 Free PMC article.

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