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Glial-derived mitochondrial signals affect neuronal proteostasis and aging.
Bar-Ziv R, Dutta N, Hruby A, Sukarto E, Averbukh M, Alcala A, Henderson HR, Durieux J, Tronnes SU, Ahmad Q, Bolas T, Perez J, Dishart JG, Vega M, Garcia G, Higuchi-Sanabria R, Dillin A. Bar-Ziv R, et al. Among authors: garcia g. Sci Adv. 2023 Oct 13;9(41):eadi1411. doi: 10.1126/sciadv.adi1411. Epub 2023 Oct 13. Sci Adv. 2023. PMID: 37831769 Free PMC article.
Spatial regulation of the actin cytoskeleton by HSF-1 during aging.
Higuchi-Sanabria R, Paul JW 3rd, Durieux J, Benitez C, Frankino PA, Tronnes SU, Garcia G, Daniele JR, Monshietehadi S, Dillin A. Higuchi-Sanabria R, et al. Among authors: garcia g. Mol Biol Cell. 2018 Oct 15;29(21):2522-2527. doi: 10.1091/mbc.E18-06-0362. Epub 2018 Aug 22. Mol Biol Cell. 2018. PMID: 30133343 Free PMC article.
UPRER promotes lipophagy independent of chaperones to extend life span.
Daniele JR, Higuchi-Sanabria R, Durieux J, Monshietehadi S, Ramachandran V, Tronnes SU, Kelet N, Sanchez M, Metcalf MG, Garcia G, Frankino PA, Benitez C, Zeng M, Esping DJ, Joe L, Dillin A. Daniele JR, et al. Among authors: garcia g. Sci Adv. 2020 Jan 1;6(1):eaaz1441. doi: 10.1126/sciadv.aaz1441. eCollection 2020 Jan. Sci Adv. 2020. PMID: 31911951 Free PMC article.
Beyond the cell factory: Homeostatic regulation of and by the UPRER.
Metcalf MG, Higuchi-Sanabria R, Garcia G, Tsui CK, Dillin A. Metcalf MG, et al. Among authors: garcia g. Sci Adv. 2020 Jul 15;6(29):eabb9614. doi: 10.1126/sciadv.abb9614. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32832649 Free PMC article. Review.
Divergent Nodes of Non-autonomous UPRER Signaling through Serotonergic and Dopaminergic Neurons.
Higuchi-Sanabria R, Durieux J, Kelet N, Homentcovschi S, de Los Rios Rogers M, Monshietehadi S, Garcia G, Dallarda S, Daniele JR, Ramachandran V, Sahay A, Tronnes SU, Joe L, Dillin A. Higuchi-Sanabria R, et al. Among authors: garcia g. Cell Rep. 2020 Dec 8;33(10):108489. doi: 10.1016/j.celrep.2020.108489. Cell Rep. 2020. PMID: 33296657 Free PMC article.
Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization.
Moehle EA, Higuchi-Sanabria R, Tsui CK, Homentcovschi S, Tharp KM, Zhang H, Chi H, Joe L, de Los Rios Rogers M, Sahay A, Kelet N, Benitez C, Bar-Ziv R, Garcia G, Shen K, Frankino PA, Schinzel RT, Shalem O, Dillin A. Moehle EA, et al. Among authors: garcia g. Sci Adv. 2021 Oct 29;7(44):eabj6818. doi: 10.1126/sciadv.abj6818. Epub 2021 Oct 29. Sci Adv. 2021. PMID: 34714674 Free PMC article.
Hijacking Cellular Stress Responses to Promote Lifespan.
Dutta N, Garcia G, Higuchi-Sanabria R. Dutta N, et al. Among authors: garcia g. Front Aging. 2022 Mar 24;3:860404. doi: 10.3389/fragi.2022.860404. eCollection 2022. Front Aging. 2022. PMID: 35821861 Free PMC article. Review.
2,784 results