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Visualising and semi-quantitatively measuring brain fluid pathways, including meningeal lymphatics, in humans using widely available MRI techniques.
Sennfält S, Thrippleton MJ, Stringer M, Reyes CA, Chappell F, Doubal F, Garcia DJ, Zhang J, Cheng Y, Wardlaw J. Sennfält S, et al. Among authors: garcia dj. J Cereb Blood Flow Metab. 2023 Oct;43(10):1779-1795. doi: 10.1177/0271678X231179555. Epub 2023 May 31. J Cereb Blood Flow Metab. 2023. PMID: 37254892 Free PMC article.
Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3.
Clancy U, Garcia DJ, Stringer MS, Thrippleton MJ, Valdés-Hernández MC, Wiseman S, Hamilton OK, Chappell FM, Brown R, Blair GW, Hewins W, Sleight E, Ballerini L, Bastin ME, Maniega SM, MacGillivray T, Hetherington K, Hamid C, Arteaga C, Morgan AG, Manning C, Backhouse E, Hamilton I, Job D, Marshall I, Doubal FN, Wardlaw JM. Clancy U, et al. Among authors: garcia dj. Eur Stroke J. 2021 Mar;6(1):81-88. doi: 10.1177/2396987320929617. Epub 2020 Jun 5. Eur Stroke J. 2021. PMID: 33817338 Free PMC article.
Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage.
Manning C, Stringer M, Dickie B, Clancy U, Valdés Hernandez MC, Wiseman SJ, Garcia DJ, Sakka E, Backes WH, Ingrisch M, Chappell F, Doubal F, Buckley C, Parkes LM, Parker GJM, Marshall I, Wardlaw JM, Thrippleton MJ. Manning C, et al. Among authors: garcia dj. Magn Reson Med. 2021 Oct;86(4):1888-1903. doi: 10.1002/mrm.28833. Epub 2021 May 18. Magn Reson Med. 2021. PMID: 34002894
Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease.
Zhang JF, Lim HF, Chappell FM, Clancy U, Wiseman S, Valdés-Hernández MC, Garcia DJ, Bastin ME, Doubal FN, Hewins W, Cox SR, Maniega SM, Thrippleton M, Stringer M, Jardine C, McIntyre D, Barclay G, Hamilton I, Kesseler L, Murphy M, Perri CD, Wu YC, Wardlaw JM. Zhang JF, et al. Among authors: garcia dj. Neurobiol Aging. 2021 Oct;106:130-138. doi: 10.1016/j.neurobiolaging.2021.06.013. Epub 2021 Jun 21. Neurobiol Aging. 2021. PMID: 34274698
Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.
Quick S, Procter TV, Moss J, Seeker L, Walton M, Lawson A, Baker S, Beletski A, Garcia DJ, Mohammad M, Mungall W, Onishi A, Tobola Z, Stringer M, Jansen MA, Vallatos A, Giarratano Y, Bernabeu MO, Wardlaw JM, Williams A. Quick S, et al. Among authors: garcia dj. Acta Neuropathol. 2022 Aug;144(2):283-303. doi: 10.1007/s00401-022-02441-4. Epub 2022 May 30. Acta Neuropathol. 2022. PMID: 35635573 Free PMC article.
Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project.
Blair GW, Stringer MS, Thrippleton MJ, Chappell FM, Shuler K, Hamilton I, Garcia DJ, Doubal FN, Kopczak A, Duering M, Ingrisch M, Kerkhofs D, Staals J, van den Brink H, Arts T, Backes WH, van Oostenbrugge R, Biessels GJ, Dichgans M, Wardlaw JM. Blair GW, et al. Among authors: garcia dj. Cereb Circ Cogn Behav. 2021 Jun 26;2:100020. doi: 10.1016/j.cccb.2021.100020. eCollection 2021. Cereb Circ Cogn Behav. 2021. PMID: 36324725 Free PMC article.
Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial.
Kopczak A, Stringer MS, van den Brink H, Kerkhofs D, Blair GW, van Dinther M, Reyes CA, Garcia DJ, Onkenhout L, Wartolowska KA, Thrippleton MJ, Kampaite A, Duering M, Staals J, Lesnik-Oberstein S, Muir KW, Middeke M, Norrving B, Bousser MG, Mansmann U, Rothwell PM, Doubal FN, van Oostenbrugge R, Biessels GJ, Webb AJS, Wardlaw JM, Dichgans M; TREAT-SVDs collaborators. Kopczak A, et al. Among authors: garcia dj. Lancet Neurol. 2023 Nov;22(11):991-1004. doi: 10.1016/S1474-4422(23)00293-4. Lancet Neurol. 2023. PMID: 37863608 Clinical Trial.
56 results